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chronic pancreatitis - Coggle Diagram
chronic pancreatitis
Caused by
Toxic-Metabolic: Alcohol abuse, smoking, hypercalcemia, hyperlipidemia
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Genetic: Mutations in PRSS1, CFTR, SPINK1 genes
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Obstructive Causes: Pancreatic duct strictures, tumors
Presented with
Abdominal Pain: Chronic, epigastric, radiating to the back, worsened by eating
Malabsorption: Weight loss, steatorrhea (fatty stools), vitamin deficiencies (ADEK)
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Managed with
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Pain Management: NSAIDs, opioids, nerve blocks
Enzyme Replacement: Pancreatic enzyme supplements (lipase, protease, amylase)
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Surgical Interventions: Drainage procedures, pancreatectomy (in refractory cases)
Pathophysiology
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Loss of exocrine function → Malabsorption, steatorrhea
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Diagnosed by
Imaging: CT scan, MRI/MRCP, Ultrasound (detects calcifications, ductal changes)
Functional Tests: Fecal elastase (exocrine function), 72-hour fecal fat test
Blood Tests: Amylase and lipase (may be normal), glucose levels
Defined by
Progressive inflammatory disease of the pancreas which leads to irreversible structural damage and loss of function