Please enable JavaScript.
Coggle requires JavaScript to display documents.
Hyperlipidemias (Lipoprotein metabolism II) - Coggle Diagram
Hyperlipidemias (Lipoprotein metabolism II)
Type I familial hyperchylomicronemia
a problem with LPL activity
Clinical Symptoms
Eruptive xanthomas, hepatosplenomegaly, lipemia retinalis, recurrent acute pancreatitis
Type IIa familial hypercholesterolemia
Main cause
a problem with LDL clearance (LDLR mutation) Small % of those with the disorder have a PCSK9 gain of function/ inc. function mutation
Clinical signs
xanthalesma (cholesterol deposits around eyes, zanthoma, premature athersclerosis
treatment
statins and bile acid resins; PCSK9 mAB & Ezetimibe
Type IIb familial combined hyperlipidemia
main cause
a problem with LDL clearance and VLDL (type IIa + type IV combined)
clinical signs
xanthelasma, premature atherosclerosis
treatment
medications to treat TAG (fibrates and niacin), and cholesterol lowering drugs
Type III familial dysbetalipoproteinemia
a problem with remnant clearance
clinical signs
Palmar & tuberoeruptive xanthoma, premature atherosclerosis
Type IV hypertriacylglycerolemia
a problem with VLDL
clinical signs
tuberoeruptive xanthomas, acute pancreatitis, premature atherosclerosis
treatment
Fibrates (gemfibrozil, fenofibrate) - active PPAR alpha, Niacin decreases VLDL production
