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TBI-epigenetics, Non Coding/microRNAs, Cell Function, Behavior - Coggle…
TBI-epigenetics
Calcium dependent pathway
DAXX activation
Histone modification
[Histone Code] (
https://www.cell.com/fulltext/S0092-8674(11)00891-9
) as [cellular memory] (
https://www.cell.com/neuron/fulltext/S0896-6273(15)00557-7
)
Reduced CpG methylation
Non Coding/microRNAs
DNMT downregulation -
DNA hypomethylation
DNA Methylation
TET (Demethylation)
IL6 ↓ by TET2 ↑ in microglia/macrophage
(link)
(link)
DNMT-1/3A/3B (Methylation)
Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons
(link)
1807 cytosine sites in PFC 8 months post TBI, corresponding to 837 genes, 458 of which are exclusive to neurons, 379 of which are exclusive to glia
(link)
DNMT1 activity reduces in pyramidal cells after ischemia-reperfusion injury, and 5 days post the injury, DNMT1 was localized to GABAergic neurons and astrocytes, while not microglia potentially NKCC1 expression, promoting seizures
a subpopulation of reactive microglia exhibit hypomethylation after TBI
(link)
DMNT-1 upregulation in PFC and Hippo 26 days post CCI
(link)
Weight-drop sTBI reveal colocalization of NeuN and DMNT1
(link)
TGF-beta ↑
(link)
BDNF ↓
AANAT ↓
(link)
serotonin -> melatonin conversion ↓
Disrupted circadian rhythm
NKCC1 ↑ in GABA neruons
(link)
(link)
Seizure
Persistent astrogliosis
(link)
GADD45
Cell Function
Behavior