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Opioid Antagonist - Coggle Diagram
Opioid Antagonist
Methylnaltrexone
Common Uses
FDA-approved for the treatment of opioid-induced constipation
Adverse Effects
Possible side effects
Stomach pain. Gas, Bloating, Mild nausea, Diarrhea, Headache, Muscle spasms, Dizziness
Mechanism of Action:
Blocks the effect of opioids in your intestine
Helps your muscles in you intestines move stool
Interactions
Interacts with many medications that can effect effectiveness
, Morphine Sulfate Liposome, Naldemedine, Naloxegol, Oxycodone, Oxymorphone
Injection, Oral tablets.
Not controlled, Need prescription
Naloxone
Interactions
No drugs effect the effectiveness
Can effect the effectiveness of other drugs
Opioid medications
Mechanism of Action:
Has a high affinity for MOR, to which it competitively binds and antagonizes
Reverses the effects of opioid-induced postoperative respiratory depression
Adverse Effects
Opioid withdrawal symptoms
Runny nose, Excessively watery eyes, Yawning, Hyperventilation, Abnormally high body temperature, Fast heart rate, Muscle aches, Nausea, Vomiting, Diarrhea, Anxiety
Common Uses
used to counteract opioid-induced postoperative respiratory depression
Injection, Nasal spray
Not controlled, OTC
Naltrexone
Common Uses
FDA-approved, used to treat alcohol abuse and opioid dependence
Interactions
No drugs effect the effectiveness
Can effect the effectiveness of other drugs
Opioid medications, cough/cold medications, and some anti-diarrheal medications
Mechanism of Action:
Primarily binds at the mu opioid receptors
Binding to these receptors, it blocks the euphoric effects of opioids or alcohol
Adverse Effects
Opioid withdrawal symptoms
Runny nose, Excessively watery eyes, Yawning, Hyperventilation, Abnormally high body temperature, Fast heart rate, Muscle aches, Nausea, Vomiting, Diarrhea, Anxiety
Injection, Oral tablets.
Not controlled, Need prescription
Nalmefene
Interactions
No drugs effect the effectiveness
Common Uses
FDA-approved to treat acute opioid overdose
Is similar to naloxone, but last longer in your system
Adverse Effects
Opioid withdrawal symptoms
Runny nose, Excessively watery eyes, Yawning, Hyperventilation, Abnormally high body temperature, Fast heart rate, Muscle aches, Nausea, Vomiting, Diarrhea, Anxiety
Mechanism of Action:
An antagonist at the mu and delta-opioid receptors and a partial agonist at the kappa-opioid receptor
Blocks ligands from binding to the opioid receptor
Injection
Not controlled, Need prescription