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MSD Skin Conditions Complete - Coggle Diagram
MSD Skin Conditions Complete
Papulosquamous, Eczematous Dermatoses and Reactive Erythemas
Eczematous (Dermatitis)
Eczematous
Dermatitis
Histology
Pathophys
Presentation
Allergic Contact
Dermatitis
Presentation
Pathophys
Histology
Atopic
Dermatitis
Pathophys
Presentation
Histology
Seborrheic Dermatitis
Treatment
Topical Antifungal (Ketoconazole)
Ciclopirox
Selenium Sulphide
Salicylic Acid
Pathophys
Malassezia Yeast that Affects Sebaceous Gland Areas
Presentation
Adult
Dandruff that affects scalp, face, trunk. Petal/Ring-shaped flaky patches with minimal itch. Winter Flares. Flexural Areas
Children/Babies
"Cradle Cap" Yellow/White crusting on top of scalp
Papules
Erythema Multiforme (Macules/Papules/Vesicles)
Presentation
Pathophys
Histology
Urticaria (Papule/Plaques)
SubTypes
Cholinergic Urticaria
Hot Shower/bath, Stress, histamine
Contact Urticaria
Allergic, HSR-I, Eosinophil
Presentation
Acute Superficial Erythema localized to dermal oedema
Elevated Papule/Plaque, reddish-white Lesions
Pathophys
HSR-I Mast Cell Degranulation and Vasodilation
Treatment
2nd generation H1 blocker (cetirizine)
Epinephrine
Lichen Planus (Papule/Plaque)
Pathophys
Histology
Presentation
Pityriasis Rosea
Pathophys
Viral Origin (with upper respiratory)
Misdiagnosed as Tinea Corpus (Ring Worm)
KOH to rule out Fungal Infection
Presentation
Acute, mild inflammatory Papular/Nummular Lesions on Trunk and Extremities
2-5cm "Hearld" Patch Round, Salmon Color, collarette scale, centrally Clear, "Christmas Tree" Dissemination
Plaques
Psoriasis (Plaque/Scale)
Presentation
Appearance/location
Silvery scaling on elbows and knees
Auspitz Sign
Pinpoint haemorrhages due to very close Dermal Pappillae
Histology
Apperance
Acanthosis with parakeratotic scaling (nucli in SC) "Test Tube Rack"
Increased Stratum Spinosum
Decreased Stratum Granulosum
Hyperkeratosis
Munro Microabscesses
Neutrophilic
infiltrate in SC
Dermal Capillary Proliferation
Pathophys
T-Cell Mediated dermatoses with dermal inflammation
Associations
onycholysis (nail pitting)
Psoriatic Arthritis
Pathophys
Presentation
Dactylitis
"Pencil-in-Cup" Deformity of DIP X-Ray
Treatment
Methotrexate
Retinoids (Immune Regulators)
Lichen Simplex Chronicus
Pathophys
Histology
Presentation
SJS.DRESS
Steven-Johnson Syndrome
Histology
Pathophys
Presentation
Drug Rash with Eosinophilia and Systemic Symptoms
Histology
Pathophys
Presentation
Vesiculobullous & Autoimmune Disorders
Autoimmune
Blistering
Bullous Pemphigoid (HSR-II)
Presentation
Pathophys
Histology
Pemphigus Vulgaris (HSR-II) Nikolsky +
Histology
Supreabasilar Acantholysis
Row of Tombstones (H&E) Eosinophils
Separation of Keratinocytes above the basal layer
(Causes Flaccid Intraepidermal Bullae
Pathophys
Autoimmune
IgG against Desmogelin 3 and Desmogelin 1
.......... ...... .(Component of desmosomes that connect keratinocytes to the Stratum Spinosum)
Presentation
Location
scalp, oral mucosa, groin and trunk
Apperance
Superficial flaccid vesicles, that
easily rupture
Epidermolysis Bullosa Simplex (AD)
Presentation
Presents Early Life
Friction-induced Skin Blistering (heals without scaring)
Affects Palms and Soles
Histology
Intraepidermal Cleavage
Pathophys
Defect in cytokeratin intermediate filaments Assembly
Cytoskeleton Disruption
Epithelial Fragility
Associations
Congenital skin aplasia (aplasia cutis congenita), ACC Histology-skin/hair development
Papules/Plaques
Dermatitis Herpetiformis (Papules/Plaque)
Pathophys
Presentation
Histology
Lupus Erythematosus
Pathophys
Histology
Presentation
Pemphigus Foliaceus (Plaque/scale)
Pathophys
Histology
Presentation
Rash
Dermatomyositis
Pathophys
Presentation
Histology
Other
Scleroderma
Presentation
Histology
Pathophys
Benign and Cystic Lesions
Benign
Females
Dermatofibroma
Pathophys
Histology
Presentation
Fibroepithelial Polyp (Skin Tag)
Pathophys
Histology
Presentation
Middle-age/Older
Acanthosis Nigricans
Phathophys
Histology
Presentation
Seborrheic Keratosis
Patholphys
Proliferation of immature keratinocytes
Keratin-filled cysts (Horn Cysts)
Leser-Trelat sign
Rapid onset of multiple seborrheic keratoses
Indicates malignancy (GI/Adenocarcinoma)
Histology
Benign Squamous Epithelial
Presentation
Well-demarcated, verrucous, benign, Scaly, pigmented, "stuck on", Rub off easily.
Other
Dermatofibroma Sarcoma Protuberans (DFSP)
Pathophys
Presentation
Histology
Cystic
Sebaceous Glands
Acne Vulgaris
Pathophys
Histology
Presentation
Epidermoid Cyst
Pathophys
Histology
Presentation
Non-Melanocytic and Malignant
Malignant
Sarcoma
Kaposi's Sarcoma
Presentation
Location
Skin, mouth, GI Tract, Respiratory
Demographic
Usually Eastern European Males With Aids/organ transplant
Associations
HHV-8 and HIV
Description
poorly demarcated lesions painful, purple nodules
Histology
Pathophys
Endothelial Malignancy
Lymphocytic infiltrate
Angiosarcoma
Pathophys
Presentation
Histology
Carcinoma
Sebaceous Carcinoma
Histology
Pathophys
Presentation
Basal Cell Carcinoma
Presentation
Histology
Pathophys
Squamous Cell Carcinoma
Presentation
Pathophys
Histology
Non-Malignant
Keratocanthoma
Presentation
Pathophys
Histology
Langerhans Cells Histiocytosis (LCH)
Presentation
Histology
Pathophys
Actinic Keratosis
Presentation (sun exposed areas)
Color
Tan/brown or pink/red lesions (yellow white scale)
Texture
scale or cutaneous horn,
dry, scaly skin
Pathophys
Increased risk of SCC
Histology
Limited to basal layers of the stratum spongiosum, as well as hyperkeratosis and parakeratosis
