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Autonomic Drugs - Coggle Diagram
Autonomic Drugs
Cholinoceptor-Activating
Structure
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Acetylcholine, methacholine, carbachol, bethanechol
MOA
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- Ach released -> PS nerves -> activates MC receptors effector cells -> alter organ function directly
- Ach released -> PS nerves -> interacts with MC receptors on nerve terminals -> modulate release of NT
Ach release + circulating MC agonists indirectly -> alter organ function -> modulating effects of PSNS/SNS + nonadrenergic, noncholinergic systems (NANC)
Cellular events -> MC receptors activated -> one or more serve as second messengers -> MC activation
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MC agonist binding -> M1, M3, & M5 receptors activates -> inositol trisphosphate (IP3), diacylglycerol (DAG) cascade
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ADME
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Methacholine/bethanechol -> reduces potency -> nicotinic receptors. Maintain activity -> muscarinic receptors
Tertiary natural cholinomimetic alkaloids (pilocarpine, nicotine, lobeline) -> well absorbed -> sites of administration
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