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Cancer detection in dogs using rapid Raman molecular urinalysis - Coggle…
Cancer detection in dogs using rapid Raman molecular urinalysis
Challenges Solved :check:
Early Cancer Detection
Cancer vs. Non-Cancer
92.7% accuracy
cancer types
lymphoma
urothelial carcinoma
most recognizable :star:
osteosarcome
mast cell tumors
Specificity (True Negative Rate)
90.5%
Sensitivity (True Positive Rate)
94.0%
identifying asymptomatic cases
reducing false pos/neg
Non-invasive diagnostic methods
blood test limitations
other solutions
expensive :forbidden:
imprecise :forbidden:
Connections to Global Issues
Veterinary healthcare innovation
advances in urine-based diagnostics
options for human medicine :silhouettes:
Broader Systems
Oncology
Canine breeds + predisposition
Diagnostic frameworks
algorithms for spectral analysis
Integration w/ imaging + biopsies
future improvements :confetti_ball:
expanding to other cancers :explode:
detecting subclinical disease
integration with exsisting practices :smiley:
potential home-testing kits
Testing
205 dogs :tada:
100 diagnosed with cancer :red_cross:
89 with no cancer history :check:
16 with non-neoplastic diseases :warning:
Collected Samples
cystocentesis
catheterization
"free-catch"
Analysis
ISREA
PCA
DAPC
Spectral fingerprint analysis :pencil2:
leave-one-out cross validation method :pen:
removal of background flourescence
ISREA
Savitzky-Golay
Why it works :question:
Cancer - dysregulates renal structure :red_flag:
lymphoma
disrupts renal structure
alter renal function
continuously produced "liquid biopsy" :warning:
Study Limitations
only samples from cL, UC, MCT and OS :red_flag:
different ways of collecting samples :red_flag:
effects of antineoplastic treatment :red_flag:
mixed cancers
teaching data interpertation