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14 y.o. girl, sudden onset fever (3 days before hospital admission), no…
14 y.o. girl, sudden onset fever (3 days before hospital admission), no fever free days, fever fluctuates. Given 500mg Paracetamol, fever rose again. Accompanied by pain behind the eyes and joint pain. A day before hospital admission, painless red spots observed on both legs and arms. Before admission experienced sudden nosebleed. Disease is transmitted by Mosquitoes. Public health center officer examined mosquito larvae in containers at her house.
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Dengue
Etiologi
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Vektor
nyamuk betina Aedes aegypti (utama), Aedes albopictus (sekunder)
Immunopatogenesis
Virus menyerang sel imun (dendritik, makrofag, monosit)
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Dampak
badai sitokin, kebocoran plasma, disfungsi organ
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Karakteristik
Fase febrile
emam tinggi, nyeri otot, sakit kepala (3–7 hari)
Fase kritis
kebocoran plasma, syok, risiko perdarahan (24–42 jam)
Fase pemulihan
ondisi membaik, peningkatan trombosit dan sel darah putih
Sifat Virulensi
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Replikasi RNA di retikulum endoplasma, dilindungi dari imun inang
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Epidemiologi
Menyerang 100 juta orang per tahun, menyebabkan 20.000–25.000 kematian
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