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Miro2 sulfhydration by CBS/H2S promotes human trophoblast invasion and…
Miro2 sulfhydration by CBS/H2S promotes human trophoblast invasion and migration via regulating mitochondria dynamics
Introduction
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the gaseous transmitter, hydrogen sulfide (H2S)
rescued fetus early-stage abortion in CBS+/− mice, as well as enhanced CTB (HTR-8/SVneo cell line) migration in vitro
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CSE/CBS can be translocated onto mitochondria and protect smooth muscle cells via CSE/H2S-ATP synthesis or CBS/H2S antioxidation
in hypoxia, prolonged CBS/H2S translocation onto mitochondria lead to mitochondria swelling and inhibited Ca2+-induced cyt c release in human hepatoma Hep3B cells
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Results
Decreased cystathionine β-synthetase (CBS)/H2S production in cytotrophoblast and plasma of PE patients
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