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"Cancer detection in dogs using rapid Raman molecular urinalysis"…
"Cancer detection in dogs using rapid Raman molecular urinalysis" - Dr. Ryan Senger
Future/New Challenges
renal disease detection
middle aged dogs
older dogs
periodic screening
classifying tumors
extraskeletal
appendicular
axial
Challenges Being Solved
canine cancer frequency :dog2:
1 in 4 -> neoplasia
50% over 10 -> cancer
most common breeds :dog:
Boxers
Golden Retrievers
Scottish Terriers
German Shepards
ineffective testing methods
Connections to Global Issues
similar to humans
dysregulate renal function
renal cell carcinoma
lymphoma
malignancies in organs
colon
lung
prostate
altered urine composition
healthcare delivery
time efficient :clock3:
cheap
Links to Systems
altered renal system
urine composition
function
structure
dog owner community :silhouettes:
lower veterinary bills :money_with_wings:
pet health knowledge :bulb:
human healthcare
Strategies
sample groups
Neoplastic (Cancer) group (100) :-1:
53 diagnosed with lymphoma
33 - B Cell Lymphoma
7 - T Cell Lymphoma
3 - "mixed histotype"
10 - unknown
35 - previously in chemotherapy
47 undiagnosed :question:
Healthy group (89) :check:
Urinary Tract Disease Group (16)
preparation of urine
mid-stream samples
sterile specimen cups
cystocentesis
4 weeks frozen :snowflake:
thawed in incubator
1.5 mL vials
dissolve solids
Raman Spectroscopy
Rametrix Toolbox v2.0 (Analysis)
read spectrical files
average duplicates
truncate spectra
apply baselining
remove background fluorescence
normalization of signal
wavenumber calibration
vector normalization
principal component analysis
discriminant analysis
analysis of variance
cross-validation
prediction accuracy
sensitivity
specificity
positive-predictive value
negative-predicted value
Potential Solutions
Raman spectroscopy
molecular vibration profile
computationally analyzed :computer:
statistically analyzed :chart_with_upwards_trend:
detect effects
metabolic
inflammatory
immune
physiologic
efficient
inexpensive :moneybag:
rapid
minimal preparation