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a-vO2 diff - Coggle Diagram
a-vO2 diff
O2 Utilization
^ NADH shuttles
v NADH available for lactic acid formation
^ Mitochondrial volume and enzymes
^ Rate of B-oxidation
^ Citrate level inhibits PFK and glycolysis
^ Fatty acid binding protein + fatty acid translocase (FAT)
^ Transport of FFA into ms
^ ADP transporters in the mitochondrial membrane
v ADP in cytosol --> less lactate/H+ formation + less PC depletion
^ Levels of carnitine (palmitoyltransferase + FAT)
^ Transport of FFA into mitochondria
Change in LDH isoform
Heart form (H4) has lower affinity for pyruvate = less lactate formation
O2 Delivery
^ Arterial diameter
^ Endothelial function
v SNS vasoconstriction
^ Arterial compliance
^ Capillary Density
Slower blood flow thru muscle (capillary transit time ^)
v Diffusion distance of O2
O2 Uptake
^ Myoglobin
^ Mitochondrial Volume (+ Turnover)
^ Fast-slow shift in ms fibers