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Molecular pharmacology Mind Map: Alzheimer's disease - Coggle Diagram

- - - - Administration: IV, requires hospitalization
        
        Side effects: infection risk, local edema, IS adverse effects, ARIA
        
        ARIA
        
        Linked to ApoE4 genotype
        
        Requires patient stratification
      - Requires BBB crossing
        
        Exploit BBB lack of integrity in AD patients
  - - - Muscarinic receptors
      - Nicotinic receptors
      - Expressed in:
        
        PNS
        
        Effects on other districts
        
        Reduced blood pressure
        
        Side effect: bradycardia
        
        Bladder
        
        Strongly affected by nicotine, so it cannot be used in the treatment of AD (also causes addiction
        
        CNS
        
        Muscarinic agents affect the CNS
        
        Side effects: hallucinations, visual distortions
    - - Agonists of muscarinic receptors
      - AchE inhibitors
        
        Therapeutic modality: small molecules via OS