Please enable JavaScript.
Coggle requires JavaScript to display documents.
TOPOGRAPHICAL AND STEREOCHEMICAL CONSIDERATIONS - Coggle Diagram
TOPOGRAPHICAL AND STEREOCHEMICAL CONSIDERATIONS
CHIRALITY AND ENANTIOMERS
mirror images
same physical and chemical properties
difference: ability to rotate (polarized light)
Ariëns
eutomer
more potent isomer
distomer
less potent isomer
the ratio of them: eudismic radio
Relationships:
one of them is really harmful
both are desiderable
different therapeutic activities
opposite effects
the same isomer interacts with different receptors
Easson and Stedman
three-point attachment (binding sites)
GEOMETRIC ISOMERS. DIASTEREOMERS
not mirror images
different compounds
different energy and stability
they can be easily separated
CONFORMATIONAL ISOMERS
geometric
they can not be separated
free rotation over the single bindings
receptors can only bind one
the energy involved to the active conformation must be compensated by the binding energy
the energy determines the amount (indirectly)