Human beings and health

Levels of organisation

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Cells

Characteristics

Types of cell

Eukaryotic cells have a nucleus (humans)

Prokaryotic cells have no nucleus (bacteria)

Humans beings are made of hundreds of billions of cells


Cells have very different shapes, sizes and functions

The diameter of most cells is between 0,5 and 25 ...


The average weight of a cell is 1 ng

Human cells are aerobic which means they obtein energy from oxygen

Tissues, organs and organ systems

Tissue is made up of cells of a similar type that work together to carry out specific functions

Types

Connective tissue

Muscle tissue

Epithelial tissue

Nervous tissue

Conective tissue supports, protects and connets other tissues. It is made by cells that secrete substances that form the intercellular matrix

Types

Connective tissue

Adipose tissue

Cartilaginous tissue

Bone tissue

Blood tissue

Surrounds and connects organs and has a gel-like intercellular matrix

It stores lipids for protection and energy reserves

It supports the skeleton by forming cartilage. It has a solid, elastic intercellular matrix

It has a hard, solid extracellular matrix. It supports the body

It consists on a liquid intercellular matrix called plasma, red and white blood cells and platelets. It transports nutrients, hormons and waste

Muscle tissue fibres contract when they are stimulated producing movement

Types

Smooth muscle tissue

Skeletal muscle tissue

Cardiac muscle tissue

It is found in the hollow organs. Its contraction is responsible for the slow and involuntary movements of these organs

It only exists in the heart. Its contraction is fast and involuntary

It covers the skeleton. Its responsible for most fast and voluntary movements

Epithelial tissue cover both external and internal surfaces of the body acting as a barrier between distinct enviroments

Types

Covering and lining epithelium

Glandular epithelium

It covers the outside of the body and also lines internal organs and cavities

It forms exocrine and endocrine glands which secrete substances for secretion and hormones to the blood respectively

It transmits nerve impulses to comunicate the body and the brain. It consists of neurons which are protected by neuroglia cells

Health and illness

Health

Concept of health

Health is a state of complete physical, mental and social well-being and not only the absence of disease

Determinants of health

Biological factors

  • Genetic inheritance
  • Age

Enviroment

  • Pollution
  • Weather
  • Radiation
  • Trauma
  • Stress
  • Pathogenic microorganisms

Life style

  • Diet
  • Drugs
  • Physical exercise

Health care sector

  • Quality
  • Accessibility
  • Amplitud and coverage

Illness

Concept of illness

Illness occurs when one or more of the body's organs does not function correctly

Indicators of illness

Symptoms

These are only felt or experienced by the patient (pain, tiredness...)

Signs

These are objective indicators and can be seen by other people, detected in test or observed in examinations (temperature, rashes...)

Classification

Infectious illness

It is caused by transmittable pathogens such as virus, bacteria, fungi and protozoa

Non-infectious illness

It is not caused by pathogens so cannot be transmitted between human beings

Types of transmission

Direct transmission

Pathogens are transferred directly from the infected person (host) to another person via physical contact (touching, kissing) or through the air (airbone saliva droplets)

Indirect transmission

Pathogens are transferred via and intermediary from the host to another person (food. water, eating utensils)

Human defenses

External defenses

External defenses are non-specific, meaning they react in the same way to all microorganisms

Physical defenses

They are surfaces which separate the inside of the body from the outside.


Skin covers the outside of the body and mucous membranes cover digestive, respiratory and reproductive cavities

Chemical defenses

They are pathogen-blocking secretions

Biological defenses

They include bacterial flora found on the skin and mucous membranes


They are good for us as they produce natural antibiotics that protect the body from other pathogens

Internal defenses

Phagocytosis

Beginning of inflammation

Fail of external defenses

  • Body temperature increases to avoid the pathogen to multiply
  • Blood vessels dilates and blood flow increases
  • Chemical messengers are released to attract macrophages
  • The skin becomes swollen and red

External defenses fail and the pathogen enters the body for the first time

White blood cells called phagocytes surround the microorganism using projections of their cell membrane called pseudopods and eliminate it in the form of pus

How do macrophages differentiate pathogenic cells from our body's own?

All cells of our body have the same membrane antigen

Phagocytes have a special receptor to detect our own membrane antigens and not attack our body cells

Phagocytes can detect foreign membrane antigens. In this case they phagocyte the pathogen

Fighting illness

Presentation of antigens

Activation of B lymphocyte

Destruction of damage cells

Phagocytes present the antigen of the pathogen to T lymphocyte and activate them

T lymphocyte activate B lymphocyte

T lymphocyte destroy damaged cells

Production of antibodies

Antibody release

Memory cell formation

B lymphocyte starts producing antibodies (it takes 4-5 days)

B lymphocyte release a large quantity of antibodies that destroy the pathogen

Some B lymphocyte become memory cells and stay in our body for years (immune memory)

Fail of external defenses

Quick response of the immune system

External defenses fail again and the pathogen enters the body for the second time

All the processes mention before take place again but this time memory cells produce antibodies extremely fast and in a much larger quantity so the pathogen does not have time to cause any damage

Prevention and treatment

Prevention

Hygiene

Wash your hands frequently


Cover your mouth and use tissues when coughing and sneezing


Always wash and disinfect cuts

Vaccination

Thanks to vaccination you can improve immunity to certain pathogens and eradicate certain dangerous illneses

Lifestyle

Get a good night sleep


Eat a balanced diet


Do not smoke or do drugs

Vaccines are infectious disease prevention methods

Vaccination involves introducing deactivated antigens of a pathogen (or the pathogen itself dead or harmless)

Our body will react with the immunological response, creating memory cells. (It also creates antibodies that will be lost via urine over time)

Next time the real pathogen enters the body, these memory cells will recognise it quicly and destroy it

If enough people is vaccinated, the pathogen will not be able to be transferred and the illness may possibly be erradicated

Treatment

Antibiotics

Fungicides

Antisera

Antivirals

They stop bacteria growing and multiplying


They cannot be used for treating other than bacteria

They kill or stop the growth of fungus

They are antibodies extracted from the blood of a previous infected animal


It is usually used to treat poisonous animal bites

They kill parasitic viruses. Few can be used as they can also damage our own cells