Human beings and health
Levels of organisation
Cells
Characteristics
Types of cell
Eukaryotic cells have a nucleus (humans)
Prokaryotic cells have no nucleus (bacteria)
Humans beings are made of hundreds of billions of cells
Cells have very different shapes, sizes and functions
The diameter of most cells is between 0,5 and 25 ...
The average weight of a cell is 1 ng
Human cells are aerobic which means they obtein energy from oxygen
Tissues, organs and organ systems
Tissue is made up of cells of a similar type that work together to carry out specific functions
Types
Connective tissue
Muscle tissue
Epithelial tissue
Nervous tissue
Conective tissue supports, protects and connets other tissues. It is made by cells that secrete substances that form the intercellular matrix
Types
Connective tissue
Adipose tissue
Cartilaginous tissue
Bone tissue
Blood tissue
Surrounds and connects organs and has a gel-like intercellular matrix
It stores lipids for protection and energy reserves
It supports the skeleton by forming cartilage. It has a solid, elastic intercellular matrix
It has a hard, solid extracellular matrix. It supports the body
It consists on a liquid intercellular matrix called plasma, red and white blood cells and platelets. It transports nutrients, hormons and waste
Muscle tissue fibres contract when they are stimulated producing movement
Types
Smooth muscle tissue
Skeletal muscle tissue
Cardiac muscle tissue
It is found in the hollow organs. Its contraction is responsible for the slow and involuntary movements of these organs
It only exists in the heart. Its contraction is fast and involuntary
It covers the skeleton. Its responsible for most fast and voluntary movements
Epithelial tissue cover both external and internal surfaces of the body acting as a barrier between distinct enviroments
Types
Covering and lining epithelium
Glandular epithelium
It covers the outside of the body and also lines internal organs and cavities
It forms exocrine and endocrine glands which secrete substances for secretion and hormones to the blood respectively
It transmits nerve impulses to comunicate the body and the brain. It consists of neurons which are protected by neuroglia cells
Health and illness
Health
Concept of health
Health is a state of complete physical, mental and social well-being and not only the absence of disease
Determinants of health
Biological factors
- Genetic inheritance
- Age
Enviroment
- Pollution
- Weather
- Radiation
- Trauma
- Stress
- Pathogenic microorganisms
Life style
- Diet
- Drugs
- Physical exercise
Health care sector
- Quality
- Accessibility
- Amplitud and coverage
Illness
Concept of illness
Illness occurs when one or more of the body's organs does not function correctly
Indicators of illness
Symptoms
These are only felt or experienced by the patient (pain, tiredness...)
Signs
These are objective indicators and can be seen by other people, detected in test or observed in examinations (temperature, rashes...)
Classification
Infectious illness
It is caused by transmittable pathogens such as virus, bacteria, fungi and protozoa
Non-infectious illness
It is not caused by pathogens so cannot be transmitted between human beings
Types of transmission
Direct transmission
Pathogens are transferred directly from the infected person (host) to another person via physical contact (touching, kissing) or through the air (airbone saliva droplets)
Indirect transmission
Pathogens are transferred via and intermediary from the host to another person (food. water, eating utensils)
Human defenses
External defenses
External defenses are non-specific, meaning they react in the same way to all microorganisms
Physical defenses
They are surfaces which separate the inside of the body from the outside.
Skin covers the outside of the body and mucous membranes cover digestive, respiratory and reproductive cavities
Chemical defenses
They are pathogen-blocking secretions
Biological defenses
They include bacterial flora found on the skin and mucous membranes
They are good for us as they produce natural antibiotics that protect the body from other pathogens
Internal defenses
Phagocytosis
Beginning of inflammation
Fail of external defenses
- Body temperature increases to avoid the pathogen to multiply
- Blood vessels dilates and blood flow increases
- Chemical messengers are released to attract macrophages
- The skin becomes swollen and red
External defenses fail and the pathogen enters the body for the first time
White blood cells called phagocytes surround the microorganism using projections of their cell membrane called pseudopods and eliminate it in the form of pus
How do macrophages differentiate pathogenic cells from our body's own?
All cells of our body have the same membrane antigen
Phagocytes have a special receptor to detect our own membrane antigens and not attack our body cells
Phagocytes can detect foreign membrane antigens. In this case they phagocyte the pathogen
Fighting illness
Presentation of antigens
Activation of B lymphocyte
Destruction of damage cells
Phagocytes present the antigen of the pathogen to T lymphocyte and activate them
T lymphocyte activate B lymphocyte
T lymphocyte destroy damaged cells
Production of antibodies
Antibody release
Memory cell formation
B lymphocyte starts producing antibodies (it takes 4-5 days)
B lymphocyte release a large quantity of antibodies that destroy the pathogen
Some B lymphocyte become memory cells and stay in our body for years (immune memory)
Fail of external defenses
Quick response of the immune system
External defenses fail again and the pathogen enters the body for the second time
All the processes mention before take place again but this time memory cells produce antibodies extremely fast and in a much larger quantity so the pathogen does not have time to cause any damage
Prevention and treatment
Prevention
Hygiene
Wash your hands frequently
Cover your mouth and use tissues when coughing and sneezing
Always wash and disinfect cuts
Vaccination
Thanks to vaccination you can improve immunity to certain pathogens and eradicate certain dangerous illneses
Lifestyle
Get a good night sleep
Eat a balanced diet
Do not smoke or do drugs
Vaccines are infectious disease prevention methods
Vaccination involves introducing deactivated antigens of a pathogen (or the pathogen itself dead or harmless)
Our body will react with the immunological response, creating memory cells. (It also creates antibodies that will be lost via urine over time)
Next time the real pathogen enters the body, these memory cells will recognise it quicly and destroy it
If enough people is vaccinated, the pathogen will not be able to be transferred and the illness may possibly be erradicated
Treatment
Antibiotics
Fungicides
Antisera
Antivirals
They stop bacteria growing and multiplying
They cannot be used for treating other than bacteria
They kill or stop the growth of fungus
They are antibodies extracted from the blood of a previous infected animal
It is usually used to treat poisonous animal bites
They kill parasitic viruses. Few can be used as they can also damage our own cells