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METABOLISM REACTIONS - Coggle Diagram
METABOLISM REACTIONS
PHASE I
OXIDATION
C-C
AROMATIC HYDROXYLATION
the epoxide is always created
pattern of 3 products (experimental)
The metabolite in which happen the transposition (of the original group) is called NIH
adding -OH groups to the aromatic ring in the drug
CARBONS ADJACENT TO SP2 GROUP
ALKENE EPOXIDATION
W AND W-1
SPECIAL SITUATION
C-N
DEAMINATION
N-OXIDATION
N-DEALKYLATION
C-S
S-DEALKYLATION
DESULFURATION
S-OXIDATION
C-O
REDUCTION
REDUCION OF CARBONYL GROUP
NITRO GROUP REDUCTION
AZO REDUCTION
AZIDA GROUP REDUCTION
REDUCTIVE HALOGENATION
HYDROLYSIS
AMIDE
amine and carboxylic acid
ESTER
alcohol and carboxylic acid
high lipo. to less lipo.
PHASE II
less lipo. to high hydro.
drug + endogenous molecule -> conjugate
phase I metabolite + endogenous molecule -> conjugate
endogenous molecule
glucuronic acid
O, N, S, C
sulphate
amino acid
GSH
acetyl
exception
methyl
exception