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Three important immunity-related genes, SNP, Genotyping, qPCR, Sanger…
Three important immunity-related genes
NLRC3 (nucleotide-oligomerization domain (NOD)-like receptor sub-family C)
IL4R (interleukin 4 receptor)
C4 (complement cmponent 4)
Can respond to infection by Aeromonas hydrophila in the spleen of striped catfish
However, their association with resistance against are unknown
Determined
NLRC3, IL4R, C4 were strongly induced by A.h infection
NLRC3: 3 SNPs
IL4R: 2 SNPs
C4: 2 SNPs
Strongly a relationship between the NLRC3, IL4R, C4 polymorphisms and A. hydrophila resistance
NLRC3 gene could be used as a candidate marker for genetic selection of A. hydrophila-resistant striped catfish
three SNP loci showed strong pairwise linkage disequilibrium, and the haplotype AGC generated with these three SNPs was associated with resistance to A. hydrophila
The objective was to examine whether SNPs in NLRC3, IL4R, and C4 are associated with A. hydrophila resistance in striped catfish.
SNP
Performed
Genotyping
qPCR
Sanger sequencing
analyzed the correlation between SNPs
and resistance to A. hydrophila infection
Result