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Pharmcogenetics ILA - Coggle Diagram

- - - - Warfarin -prevents blood from clotting
        
        High dose of anti-coagulants makes it high risk of bleeding
    - - Fast metabolizer: omeprazole (proton pump inhibitor) increased to counter decreased therapeutic effects
        
        Omeprazole used when there's too much acid in the stomach. Inhibit the proton pumps to decrease acidity.
        
        Rx for GERD and other conditions
    - - Poor metabolizer: Increased risk to tricyclic antidepressants
        
        Fast metabolizers: Decreased effects
  - - - Slow acetylators highly prevalent in half of European and African derived pop.
  - - - Azathioprine (immunosuppressant)
      - 6-mercaptopurine (anti-neoplastic drug)
  - - - Irinotecan (anti-neoplastic drug)
        
        Targets topoisomerase 1
  - - - Anti-malarial drugs
        
        Primaquine
        
        Chloroquine
      - Rasburicase
        
        Lowers uric acid during chemo
        
        Does so by converting uric acid to allantoin. Unlike allopurinol which stops uric acid production in the purine salvage pathway by blocking xanthine oxidase.
        
        Same class of drug as allopurinol, a drug used to lower uric acid.
      - Drugs increasing oxidative stress
        
        Sulfonamides
        
        Some NSAIDs
      - Most common in African, mediterranean, or South Asians
  - - - Decreased dose requirements for one variant.
  - - - Also used to treat GI tumors. However, biopsy must confirm presence of c-kit since imatinib targets it.