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Cycle of viral replication, RNA transcription - Coggle Diagram
Cycle of viral replication, RNA transcription
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Transcription
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Occurs by
- Action of trans-acting proteins that are either absent, or at low levels in virions.
- Regulatory role of promoter RNA secondary structure along with the action of specific viral.
- Alteration of the virus RNA synthesizing enzyme complex that changes its role as “transcriptase” to a “replicase”.
- Combination of the above.
Stages of transcription
The polymerase synthesizes a new complementary strand, without dissociating from the template, and by repeated addition of a nucleoside monophosphate to the 3' end of the growing RNA strand.
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-The polymerase machinery is recruited by the viral promoter and synthesis begins at or near the 3' end of the template.
-primer-dependent or primer-independent (de novo) mechanism
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Leads to the release of the newly synthesized RNA strand and dissociation of the polymerase from the template.
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