AS 215 Notes
Chapter 3 - Anatomy of the Cell
Cytoplasm: includes everything but the nucleus
Cytosol: the liquid that suspends the organelles and fills the cytoplasm
Organelles: all of the parts inside of the cell that has different functions
Eukaryotic: includes a true nucleus
Prokaryotic: doesn't have a nucleus
Cytoskeleton: a structural complex that gives strength, structure, and support to the cell; affects cell division and movement of the organelles
Nucleus: the control center of the cell; controls cell activity and makes ribosomes for protein synthesis; largest part of the cell
Nuclear Envelope: a double-membrane that surrounds the nucleus which restricts and limits molecules coming in and out of the nucleus
Chromatin: strands of DNA wrapped around a histone protein that condenses into chromosomes during cell division
Nucleolus: the site of ribosome synthesis using RNA and protein units
Ribosomes: composed of two subunits: RNA and protein; the site of protein synthesis
Mitochondria: a double membrane bound organelle that has folding cristae which increases surface area for metabolic processes; produces ATP through cellular respiration
Endoplasmic Reticulum: a system of sacs that fold extending from the nuclear envelope; one having ribosomes (rough) and one without ribosomes (smooth). Its function is that it makes proteins (Rough ER) and the other (Smooth ER) makes lipids and carbohydrates.
Proteasomes: a hollowed cylinder composed of protein subunits and caps on its ends; its function is breaking down abnormal or misfolded protein molecules.
Golgi Apparatus: a network of flattened tubes that refines and alters molecules for cell usage and produces lysosomes which are vesicles made up of enzymes that digests absorbed material and waste material
Peroxisomes: membrane-bound vesicles containing enzymes. Its function is to detoxify things like alcohol and formaldehyde; removes free radicals
Vault: small tubular capsules made up of vRNA and proteins; able to fit into nuclear pore complexes to pick up or drop off molecules in the nucleus
Chapter 4 - Cell Physiology
Cells: the basic unit of all living things
Performs functions of life
- Growth
- Metabolism
- Development
- Reproduction
- Homeostasis
- Respiration
- Adaption
Cell Membrane: the barrier between the inner cytoplasm and the outside environment; the phospholipid bilayer
Ions: charged particles (also considered electrolytes because of its conductive nature in solutions)
Passive Membrane Processes: the processes that do not require ATP in order to occur
- Diffusion
- Facilitated Diffusion
- Osmosis
- Filtration
Diffusion: the kinetic movement of molecules from higher concentration to lower concentration; molecular size, liquid solubility, and molecular charge are factors that can affect movement
Facilitated Diffusion: selected carrier proteins assist in the movement of moles across a concentration gradient; limited by number of proteins & requires no energy from the cell
Osmosis: the passive movement of water through a semipermeable membrane from dilute solution to a more concentrated one; water is meant to balance (concentration balance)
Filtration: the movement of molecules based on pressure gradient; liquid may be pushed through if the pressure on one side is greater than the other side
- Hypotonic: the concentration is too high inside the cell and it's going to burst
- Hypertonic: the concentration is too low inside the cell and it's going to shrink
- Isotonic: when the concentration is balanced so the cell is normal
DNA Replication: DNA will replicate itself inside the nucleus during interphase; at the end of it, there will be two identical DNA strands
Transcription: the process of making mRNA; using the DNA strand to make an RNA copy to perform protein synthesis
Translation: the process of turning mRNA into a protein by way of ribosomes and mRNA that shows how to make the protein using amino acids
Active Membrane Processes: the processes that do require ATP in order to occur
Active Transport: certain amino acids and ions need specific carrier proteins in order to move in and out of the cell, meaning that they'll need the energy to do so
- Symport: moves in one direction across the membrane
- Antiport: some can move in one direction; others move in the opposite direction
Cytosis: the process of bringing in nutrients and expelling waste out of the cell
- Endocytosis
- Exocytosis
Mitosis: a part of the cell cycle that involves cell division into two new daughter cells (identical)
Prophase – the chromatin condenses and coil into chromosomes with the nuclear envelope dissipating
Interphase comes before mitosis which is preparing for it through DNA replication and growth
Metaphase – the chromosomes will line up in the middle with the spindle fibers attaching to the chromosomes
Anaphase – the spindle fibers will pull apart the chromosomes into halves in prepping for the next phase
Telophase – this is where the two new daughter cells are being formed as the cell divides and through cytokinesis, the two cells are made
Genetic Mutations: during DNA replication, there can be errors made which puts in the wrong 'code' for the DNA strand and thus leads to mutations; sometimes it can be good or bad
Chapter 5 - Tissues
Epithelial Tissue – lines and protects as a lining on other tissues, can filter biochemical substances, absorb nutrients, provides sensory input, and manufactures secretions and excretions
Connective Tissue – forms structural and metabolic connections between other tissues, provides a sheath around organs and insulates the body, a reserve for energy, provides a frame support for the body, and is a medium for transport from regions of the body
Muscle Tissue – made of specialized proteins that are arranged into microfilaments and allows for contraction and movement of bones, blood, and soft tissues
Nervous Tissue – designed to receive and transmit electrical and chemical signals #
Characteristics of Epithelia
- Organized into tightly packed groups that forms sheets
- Each cell is polar, having an apical and basal surface
- Having lateral surfaces that connects with neighboring cells through junction complexes
- Are avascular, relying on underlying connective issue for blood and oxygen
- Are innervated and provides sensory input
Classification of Epithelia
Number of layers of cells
- Stratified
- Simple
Shape of cells
- Squamous
- Cuboidal
- Columnar
Presence of surface specialization
- Cilia, microvilli, keratin, etc.
Cellular Attachments
Junction Complexes: a strong attachment that only utilizes a small portion of the cell membrane to make an attachment
Tight Junctions: the fusion of outermost layers of the plasma membrane of adjoining cells
Desmosome: a type of junction that connect adjacent cells with filaments tethering the plasma membrane together; hemidesmosomes are half of desmosomes that link epithelial cells to the basement membrane
Gap Junctions: an attachment using connexons (tubular channel proteins) and directly links the cytoplasm of two cells together
Glands
Endocrine Glands: produce secretions that are distributed throughout the body and doesn’t have any tubules or ducts for transport. They produce hormones that are sent through the bloodstream. The pituitary gland in the brain is an example of an endocrine gland.
Exocrine Glands: have ducts, and the secretions often act locally rather than circulating through the bloodstream. The salivary gland in the mouth is an example of an exocrine gland.
Characteristics of Connective Tissue
- Most abundant tissue by weight
- Vascularized (having blood vessels)
- Has 2 distinct components
- Ground substances
(can range from liquid to solid) - Extracellular fibers
(collagenous, reticular, and elastic) - Cell Types
(fixed; fibroblasts, adipocytes, reticular cells)
(wandering; mast cells, leukocytes, macrophages)
Types of Tissues
Proper
Specialized
Loose
Dense
- Regular
(tendons, ligaments) - Irregular
(scar tissue, dermis) - Elastic
(Tendons, wall of arteries)
- Areolar
(between muscles; provides nutrients) - Adipose
(fat) - Reticular
(spleen, lymph nodes, bone marrow)
Blood #
Bone #
Cartilege
- Hyaline (ribs, trachea, c-rings) (most common)
- Elastic (pinna of ear, epglottis) (flexible)
- Fibro (pubic & mandibular symphysis) (tough, no bending)
Types of Tissues
Skeletal (over bones)
Cardiac (heart only)
Smooth (organs)
- Voluntary
- Striated
- Multi-nucleated
- Involuntary
- Striated
- Intercalated Disks
- Involuntary
- Non-striated
Parts of Neuron
Neuron
Dendrites: receive info
Axon: sends info from nucleus
Cell Body (Soma)
Neuroglial Cells (Supporting Cell)
Telodentrities: sends info
Chapter 12 - Blood
Blood:
- transport (O2, CO2, waste)
- regulation (temperature, ph)
- defense (WBC's, platelets)
Hematopoesis: all blood cell productions
Erythropoesis: production of erythrocytes (red blood cells)
Leukopoesis: production of leukocytes (white blood cells)
Thrombopoesis: production of thrombocytes (platelets)
- made by megakaryocytes in the bone marrow
Red Blood Cells:
- Biconcave
- Anucleated
- Contain hemoglobin
Components of Blood
Cellular:
- RBC's
- WBC's
- Platelets (helps with clotting)
Plasma:
- Water
- Ions
- Waste
- Nutrients
- Protein
Hematocrit: Packed Cell Volume
Anemia
Polycythemia
Plasma vs. Serum
Plasma: has clotting factors
Serum: no clotting factors
White Blood Cells/Leukocytes
Granulocytes: contains granules
Neutrophil:
- Multi-lobed nucleus
- First responders
- Granules don't tend to stain
- Help fight infection
- Most cmmon in dogs, cats, and horses
Basophil:
- Bi-lobed nucleus
- Granules stain blue/purple
- Heparin & Histamine
- Cause inflammation
- Allergic Reaction
Eosinophil:
- Bi-lobed nucleus
- Granules stain red/pink
- Deals with parasites & allergies
- Large in horses
Agranulocytes: does not contain granules
Lymphocyte:
- Large nucleus
- Immune response
(T & B cells) - Most common in ruminants & pigs
Monocyte:
- Phagocytosis
- In blood
- Horseshoe nucleus
Macrophage:
- In tissue
An abundant tissue in the body that provides cushioning and lining of the organs for protection
A web of tightly connected tissue, less common than loose connective tissue that still have fibroblasts that supply fiber and ground substances
Areolar: a tangle of random fibers and cells suspended in thick ground substance; mostly fibroblasts & provide nutrients, surrounds and supports, present in all mucous membranes
Adipose:
Reticular:
A fluid connective tissue made up of:
- whole blood
- peripheral blood
- plasma
Intravascular Hemolysis: the destruction of RBC's inside the blood vessels; RBC's are ruptured & hemoglobin released into blood vessel, picked up by macrophages to be broken down; excess hemoglobin are taken to the kidney to be expelled
Extravascular Hemolysis: the destruction and breakdown of RBC's outside of the blood vessel; RBC removed from circulation by macrophages and the hemoglobin and its components are going to be broken down and used for other purposes such as production of new RBC or making bile in the stomach
Lymphatic System:
- Removal of excessive fluid
- Waste material transport
- Filtration of lymph
- Protein transpart
Chapter 7 - The Skeletal System
Bone:
- A rigid structure made up of a matrix
- Contains osteoblasts, osteocytes, and osteoclasts
- Ossification: the hardening of the matrix into bone
Functions
Support:
- bones serve as scaffolding for the rest of the body such as the tissues and muscles in our body
- the body structure is centric around the bones
Protection:
- the bones serve as a barrier/shield for delicate and vital organs in our body such as our brain with the skull, our ribs for our lungs and heart.
Leverage:
- the attachment of skeletal muscle to bones allow for movement of the body parts
Storage:
- bones act as a storage unit for important minerals, mainly calcium and it allows the body to deposit and withdraw calcium as needed for functions
Blood cell formation:
- in the bone marrow, hematopoiesis occurs
Types
Cancellous Bone:
- Spongy-like
- Formed with spicules of bone and spaces within
- Occupied by bone marrow
- Allows it to be lightweight without sacrificing structure
Compact Bone:
- Dense and heavy
- Makes up long shaft of bones in a thin layer and outside of all bones
- The Haversian System: made up of tiny, thin, and compact cylinders that run lengthwise of the bone
Osteoblasts: builds new bones
Osteocytes: mature bone cell
Osteoclasts: 'eats'/remodel old bones
Haversian canals run nerves, lymph and blood vessels through the bones and Volksmann's canals run perpendicular for blood and lymph vessels to pass through
Canaliculi:
- allows for osteoblasts to exchange waste and minerals in the bone
Nutrient Foramina:
- allows for the carrying of blood supply in and out of the bones
- a hole in the large & long bones
Bone Formation
Endochondral Bone Formation:
- a cartilage template replaced by bones
- primary growth center (diaphysis)
- secondary growth center (epiphysis)
Intramembranous Bone Formation:
- bone develop from fibrous membrane tissue
- occurs only in some skull bones
Types of Joints
Fibrous Joints
- Immovable
- Firmly united by fibrous tissue
- Ex: plates of the skull
Cartilaginous Joints
- Slightly movable (rocking motion)
- Ex: intervertebral discs
Synovial Joints
- Freely movable
- Articular surface on bones
- Articular cartilage covering surfaces
- Joint cavity = joint space
Synovial Fluid
Synovial Membrane - Ligaments for stabilization
Hinge Joint
Gliding Joint
Ball and Socket Joint
Pivot Joint
Sarcomeres: a contractile unit of a muscle fiber with a Z lines defining its edges and made up of myofibrils (myosin and actin)
Muscle contraction is done through the myosin and actin that has been given energy by ATP
Chapter 9 - The Nervous System
Functions:
- Activities involve sensory functions, integrating function, and motor functions
- Maintains bodily functions and react to stimuli
Chapter 8 - The Muscular System
Parts of Neuron
Soma - the cell body where the nucleus is; the acting brain of the cell
Dendrites - receive stimuli & conduct it in the cell body (afferent processes)
Axon - conducts nerve impulses away from the cell body; also referred to as nerve fibers
- Covered in a fatty sheath called myelin
Myelin Sheath - made up of the cell membranes of specialized glial cells called oligodenrocytes and Schwann cells
Neuroglia - also glial cells; important in the infrastructure of the nervous system, supports and protects the neuron
Location
Peripheral Nervous System - made up of components that extend away from the central axis of the body
- Nerves that link the CNS to the rest of the body
Central Nervous System - made up of the spinal cord and brain
Impulses
Afferent Impulses:
- conduct impulses toward the CNS
Efferent Impulses:
- conducts impulses toward the CNS
Autonomic Nervous System:
- controls automatic functions such as breathing and heartrate
- handles any functions that cannot be handled consciously by the animal
Somatic Nervous System
- conscious and voluntary control over body parts such as movement of the limbs or blinking
Neuron Function
Sodium-Potassium Pump:
- Specialized molecule that help maintain cell resting state
- Pumps Na++ to the outside
- Pumps K+ to the inside
Resting Membrane Potential:
- Net negative charge
- The difference in the electrical charge across the membrane
Depolarization: the neuron goes from a negatively charged resting membrane potential to a net postiive charge where the sodium-potassium pump open to let sodium molecules into the cell
Repolarization: the potassium pumps opens up and pushes out positively charged potassium, leading the cell becoming more negative
Chapter 10 - Sense Organs
General Senses
Visercal Sensations
- Ex. hunger & thirst
- Mechanical, chemical stimulus
Touch
- Ex. touch & pressure
- Mechanical stimulus
Temperature
- Ex. heat & cold
- Thermal stimulus
Pain
- Ex. intense stimuli of any kind
- Mechanical, thermal, or chemical
- Nociceptors
Proprioception
- Ex. body position & movement
- Mechanical stimulus
Special Senses
Taste
- Papillae that lines the tongue and phargyx which detect chemical substances that sends those impulses to the brain to detect taste
Touch
Hearing
- Converts vibrations of air molecules into nerve impulses where those impulses are interpreted as sound
Smell
- Olfactory cells in the epithelial patches of the nasal passages with hairs extended into the mucous that detect the chemical substances that dissolve in the mucous, sending impulses for smell
Vision
Equilibrium
Threshold Stimulus vs. All or Nothing Principle
Chapter 14 - Cardiovascular System
The Heart:
- Located in the middle of the thoracic cavity in the mediastinum, the space between the two lungs
Layers of the Heart
Pericardium
- Pericardium Sac: contains the heart, stretches enough to allow for the heart to beat
- Serous Pericardium: consists of two layers called the parietal layer that lines the pericardial sac and the visceral layer that lines the surface of the heart
Threshold Stimulus
- Stimulus is strong enough to complete depolarization and then a nerve impulse is generated
All or Nothing Principle
- Regardless of the intensity of the stimulus, if it was sufficient to cause a neuron to fire, it will generate a nerve impulse across the neuron with uniform strength
Myocardium
- middle & thickest layer of the heart
- made up of cardiac cells that allow for stronger contractions of the heart
Epicardium
- outermost layer, also the visceral layer of the serous pericardium
Endocardium
- innermost layer of the heart
- made up of simple squamous epithelium that lines the heart and its chambers
Central Nervous System
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