AS 215 Notes

Chapter 3 - Anatomy of the Cell

Cytoplasm: includes everything but the nucleus

Cytosol: the liquid that suspends the organelles and fills the cytoplasm

Organelles: all of the parts inside of the cell that has different functions

Eukaryotic: includes a true nucleus

Prokaryotic: doesn't have a nucleus

Cytoskeleton: a structural complex that gives strength, structure, and support to the cell; affects cell division and movement of the organelles

Nucleus: the control center of the cell; controls cell activity and makes ribosomes for protein synthesis; largest part of the cell

Nuclear Envelope: a double-membrane that surrounds the nucleus which restricts and limits molecules coming in and out of the nucleus

Chromatin: strands of DNA wrapped around a histone protein that condenses into chromosomes during cell division

Nucleolus: the site of ribosome synthesis using RNA and protein units

Ribosomes: composed of two subunits: RNA and protein; the site of protein synthesis

Mitochondria: a double membrane bound organelle that has folding cristae which increases surface area for metabolic processes; produces ATP through cellular respiration

Endoplasmic Reticulum: a system of sacs that fold extending from the nuclear envelope; one having ribosomes (rough) and one without ribosomes (smooth). Its function is that it makes proteins (Rough ER) and the other (Smooth ER) makes lipids and carbohydrates.

Proteasomes: a hollowed cylinder composed of protein subunits and caps on its ends; its function is breaking down abnormal or misfolded protein molecules.

Golgi Apparatus: a network of flattened tubes that refines and alters molecules for cell usage and produces lysosomes which are vesicles made up of enzymes that digests absorbed material and waste material

Peroxisomes: membrane-bound vesicles containing enzymes. Its function is to detoxify things like alcohol and formaldehyde; removes free radicals

Vault: small tubular capsules made up of vRNA and proteins; able to fit into nuclear pore complexes to pick up or drop off molecules in the nucleus

Chapter 4 - Cell Physiology

Cells: the basic unit of all living things

Performs functions of life

  • Growth
  • Metabolism
  • Development
  • Reproduction
  • Homeostasis
  • Respiration
  • Adaption

Cell Membrane: the barrier between the inner cytoplasm and the outside environment; the phospholipid bilayer

Ions: charged particles (also considered electrolytes because of its conductive nature in solutions)

Passive Membrane Processes: the processes that do not require ATP in order to occur

  • Diffusion
  • Facilitated Diffusion
  • Osmosis
  • Filtration

Diffusion: the kinetic movement of molecules from higher concentration to lower concentration; molecular size, liquid solubility, and molecular charge are factors that can affect movement

Facilitated Diffusion: selected carrier proteins assist in the movement of moles across a concentration gradient; limited by number of proteins & requires no energy from the cell

Osmosis: the passive movement of water through a semipermeable membrane from dilute solution to a more concentrated one; water is meant to balance (concentration balance)

Filtration: the movement of molecules based on pressure gradient; liquid may be pushed through if the pressure on one side is greater than the other side

  • Hypotonic: the concentration is too high inside the cell and it's going to burst
  • Hypertonic: the concentration is too low inside the cell and it's going to shrink
  • Isotonic: when the concentration is balanced so the cell is normal

DNA Replication: DNA will replicate itself inside the nucleus during interphase; at the end of it, there will be two identical DNA strands

Transcription: the process of making mRNA; using the DNA strand to make an RNA copy to perform protein synthesis

Translation: the process of turning mRNA into a protein by way of ribosomes and mRNA that shows how to make the protein using amino acids

Active Membrane Processes: the processes that do require ATP in order to occur

Active Transport: certain amino acids and ions need specific carrier proteins in order to move in and out of the cell, meaning that they'll need the energy to do so

  • Symport: moves in one direction across the membrane
  • Antiport: some can move in one direction; others move in the opposite direction

Cytosis: the process of bringing in nutrients and expelling waste out of the cell

  • Endocytosis
  • Exocytosis

Mitosis: a part of the cell cycle that involves cell division into two new daughter cells (identical)

Prophase – the chromatin condenses and coil into chromosomes with the nuclear envelope dissipating

Interphase comes before mitosis which is preparing for it through DNA replication and growth

Metaphase – the chromosomes will line up in the middle with the spindle fibers attaching to the chromosomes

Anaphase – the spindle fibers will pull apart the chromosomes into halves in prepping for the next phase

Telophase – this is where the two new daughter cells are being formed as the cell divides and through cytokinesis, the two cells are made

Genetic Mutations: during DNA replication, there can be errors made which puts in the wrong 'code' for the DNA strand and thus leads to mutations; sometimes it can be good or bad

Chapter 5 - Tissues

Epithelial Tissue – lines and protects as a lining on other tissues, can filter biochemical substances, absorb nutrients, provides sensory input, and manufactures secretions and excretions

Connective Tissue – forms structural and metabolic connections between other tissues, provides a sheath around organs and insulates the body, a reserve for energy, provides a frame support for the body, and is a medium for transport from regions of the body

Muscle Tissue – made of specialized proteins that are arranged into microfilaments and allows for contraction and movement of bones, blood, and soft tissues

Nervous Tissue – designed to receive and transmit electrical and chemical signals #

Characteristics of Epithelia

  • Organized into tightly packed groups that forms sheets
  • Each cell is polar, having an apical and basal surface
  • Having lateral surfaces that connects with neighboring cells through junction complexes
  • Are avascular, relying on underlying connective issue for blood and oxygen
  • Are innervated and provides sensory input

Classification of Epithelia

Number of layers of cells

  • Stratified
  • Simple

Shape of cells

  • Squamous
  • Cuboidal
  • Columnar

Presence of surface specialization

  • Cilia, microvilli, keratin, etc.

Cellular Attachments

Junction Complexes: a strong attachment that only utilizes a small portion of the cell membrane to make an attachment

Tight Junctions: the fusion of outermost layers of the plasma membrane of adjoining cells

Desmosome: a type of junction that connect adjacent cells with filaments tethering the plasma membrane together; hemidesmosomes are half of desmosomes that link epithelial cells to the basement membrane

Gap Junctions: an attachment using connexons (tubular channel proteins) and directly links the cytoplasm of two cells together

Glands

Endocrine Glands: produce secretions that are distributed throughout the body and doesn’t have any tubules or ducts for transport. They produce hormones that are sent through the bloodstream. The pituitary gland in the brain is an example of an endocrine gland.

Exocrine Glands: have ducts, and the secretions often act locally rather than circulating through the bloodstream. The salivary gland in the mouth is an example of an exocrine gland.

Characteristics of Connective Tissue

  • Most abundant tissue by weight
  • Vascularized (having blood vessels)
  • Has 2 distinct components
  • Ground substances
    (can range from liquid to solid)
  • Extracellular fibers
    (collagenous, reticular, and elastic)
  • Cell Types
    (fixed; fibroblasts, adipocytes, reticular cells)
    (wandering; mast cells, leukocytes, macrophages)

Types of Tissues

Proper

Specialized

Loose

Dense

  • Regular
    (tendons, ligaments)
  • Irregular
    (scar tissue, dermis)
  • Elastic
    (Tendons, wall of arteries)
  • Areolar
    (between muscles; provides nutrients)
  • Adipose
    (fat)
  • Reticular
    (spleen, lymph nodes, bone marrow)

Blood #

Bone #

Cartilege

  • Hyaline (ribs, trachea, c-rings) (most common)
  • Elastic (pinna of ear, epglottis) (flexible)
  • Fibro (pubic & mandibular symphysis) (tough, no bending)

Types of Tissues

Skeletal (over bones)

Cardiac (heart only)

Smooth (organs)

  • Voluntary
  • Striated
  • Multi-nucleated
  • Involuntary
  • Striated
  • Intercalated Disks
  • Involuntary
  • Non-striated

Parts of Neuron

Neuron

Dendrites: receive info

Axon: sends info from nucleus

Cell Body (Soma)

Neuroglial Cells (Supporting Cell)

Telodentrities: sends info

Chapter 12 - Blood

Blood:

  • transport (O2, CO2, waste)
  • regulation (temperature, ph)
  • defense (WBC's, platelets)

Hematopoesis: all blood cell productions

Erythropoesis: production of erythrocytes (red blood cells)

Leukopoesis: production of leukocytes (white blood cells)

Thrombopoesis: production of thrombocytes (platelets)

  • made by megakaryocytes in the bone marrow

Red Blood Cells:

  • Biconcave
  • Anucleated
  • Contain hemoglobin

Components of Blood

Cellular:

  • RBC's
  • WBC's
  • Platelets (helps with clotting)

Plasma:

  • Water
  • Ions
  • Waste
  • Nutrients
  • Protein

Hematocrit: Packed Cell Volume

Anemia

Polycythemia

Plasma vs. Serum

Plasma: has clotting factors

Serum: no clotting factors

White Blood Cells/Leukocytes

Granulocytes: contains granules

Neutrophil:

  • Multi-lobed nucleus
  • First responders
  • Granules don't tend to stain
  • Help fight infection
  • Most cmmon in dogs, cats, and horses

Basophil:

  • Bi-lobed nucleus
  • Granules stain blue/purple
  • Heparin & Histamine
  • Cause inflammation
  • Allergic Reaction

Eosinophil:

  • Bi-lobed nucleus
  • Granules stain red/pink
  • Deals with parasites & allergies
  • Large in horses

Agranulocytes: does not contain granules

Lymphocyte:

  • Large nucleus
  • Immune response
    (T & B cells)
  • Most common in ruminants & pigs

Monocyte:

  • Phagocytosis
  • In blood
  • Horseshoe nucleus

Macrophage:

  • In tissue

An abundant tissue in the body that provides cushioning and lining of the organs for protection

A web of tightly connected tissue, less common than loose connective tissue that still have fibroblasts that supply fiber and ground substances

Areolar: a tangle of random fibers and cells suspended in thick ground substance; mostly fibroblasts & provide nutrients, surrounds and supports, present in all mucous membranes

Adipose:

Reticular:

A fluid connective tissue made up of:

  • whole blood
  • peripheral blood
  • plasma

Intravascular Hemolysis: the destruction of RBC's inside the blood vessels; RBC's are ruptured & hemoglobin released into blood vessel, picked up by macrophages to be broken down; excess hemoglobin are taken to the kidney to be expelled

Extravascular Hemolysis: the destruction and breakdown of RBC's outside of the blood vessel; RBC removed from circulation by macrophages and the hemoglobin and its components are going to be broken down and used for other purposes such as production of new RBC or making bile in the stomach

Lymphatic System:

  • Removal of excessive fluid
  • Waste material transport
  • Filtration of lymph
  • Protein transpart

Chapter 7 - The Skeletal System

Bone:

  • A rigid structure made up of a matrix
  • Contains osteoblasts, osteocytes, and osteoclasts
  • Ossification: the hardening of the matrix into bone

Functions

Support:

  • bones serve as scaffolding for the rest of the body such as the tissues and muscles in our body
  • the body structure is centric around the bones

Protection:

  • the bones serve as a barrier/shield for delicate and vital organs in our body such as our brain with the skull, our ribs for our lungs and heart.

Leverage:

  • the attachment of skeletal muscle to bones allow for movement of the body parts

Storage:

  • bones act as a storage unit for important minerals, mainly calcium and it allows the body to deposit and withdraw calcium as needed for functions

Blood cell formation:

  • in the bone marrow, hematopoiesis occurs

Types

Cancellous Bone:

  • Spongy-like
  • Formed with spicules of bone and spaces within
  • Occupied by bone marrow
  • Allows it to be lightweight without sacrificing structure

Compact Bone:

  • Dense and heavy
  • Makes up long shaft of bones in a thin layer and outside of all bones
  • The Haversian System: made up of tiny, thin, and compact cylinders that run lengthwise of the bone

Osteoblasts: builds new bones
Osteocytes: mature bone cell
Osteoclasts: 'eats'/remodel old bones

Haversian canals run nerves, lymph and blood vessels through the bones and Volksmann's canals run perpendicular for blood and lymph vessels to pass through

Canaliculi:

  • allows for osteoblasts to exchange waste and minerals in the bone

Nutrient Foramina:

  • allows for the carrying of blood supply in and out of the bones
  • a hole in the large & long bones

Bone Formation

Endochondral Bone Formation:

  • a cartilage template replaced by bones
  • primary growth center (diaphysis)
  • secondary growth center (epiphysis)

Intramembranous Bone Formation:

  • bone develop from fibrous membrane tissue
  • occurs only in some skull bones

Types of Joints

Fibrous Joints

  • Immovable
  • Firmly united by fibrous tissue
  • Ex: plates of the skull

Cartilaginous Joints

  • Slightly movable (rocking motion)
  • Ex: intervertebral discs

Synovial Joints

  • Freely movable
  • Articular surface on bones
  • Articular cartilage covering surfaces
  • Joint cavity = joint space
    Synovial Fluid
    Synovial Membrane
  • Ligaments for stabilization

Hinge Joint

Gliding Joint

Ball and Socket Joint

Pivot Joint

Sarcomeres: a contractile unit of a muscle fiber with a Z lines defining its edges and made up of myofibrils (myosin and actin)

Muscle contraction is done through the myosin and actin that has been given energy by ATP

Chapter 9 - The Nervous System

Functions:

  • Activities involve sensory functions, integrating function, and motor functions
  • Maintains bodily functions and react to stimuli

Chapter 8 - The Muscular System

Parts of Neuron

Soma - the cell body where the nucleus is; the acting brain of the cell
Dendrites - receive stimuli & conduct it in the cell body (afferent processes)

Axon - conducts nerve impulses away from the cell body; also referred to as nerve fibers

  • Covered in a fatty sheath called myelin

Myelin Sheath - made up of the cell membranes of specialized glial cells called oligodenrocytes and Schwann cells

Neuroglia - also glial cells; important in the infrastructure of the nervous system, supports and protects the neuron

Location

Peripheral Nervous System - made up of components that extend away from the central axis of the body

  • Nerves that link the CNS to the rest of the body

Central Nervous System - made up of the spinal cord and brain

Impulses

Afferent Impulses:

  • conduct impulses toward the CNS

Efferent Impulses:

  • conducts impulses toward the CNS

Autonomic Nervous System:

  • controls automatic functions such as breathing and heartrate
  • handles any functions that cannot be handled consciously by the animal

Somatic Nervous System

  • conscious and voluntary control over body parts such as movement of the limbs or blinking

Neuron Function

Sodium-Potassium Pump:

  • Specialized molecule that help maintain cell resting state
  • Pumps Na++ to the outside
  • Pumps K+ to the inside

Resting Membrane Potential:

  • Net negative charge
  • The difference in the electrical charge across the membrane

Depolarization: the neuron goes from a negatively charged resting membrane potential to a net postiive charge where the sodium-potassium pump open to let sodium molecules into the cell
Repolarization: the potassium pumps opens up and pushes out positively charged potassium, leading the cell becoming more negative

Chapter 10 - Sense Organs

General Senses

Visercal Sensations

  • Ex. hunger & thirst
  • Mechanical, chemical stimulus

Touch

  • Ex. touch & pressure
  • Mechanical stimulus

Temperature

  • Ex. heat & cold
  • Thermal stimulus

Pain

  • Ex. intense stimuli of any kind
  • Mechanical, thermal, or chemical
  • Nociceptors

Proprioception

  • Ex. body position & movement
  • Mechanical stimulus

Special Senses

Taste

  • Papillae that lines the tongue and phargyx which detect chemical substances that sends those impulses to the brain to detect taste

Touch

Hearing

  • Converts vibrations of air molecules into nerve impulses where those impulses are interpreted as sound

Smell

  • Olfactory cells in the epithelial patches of the nasal passages with hairs extended into the mucous that detect the chemical substances that dissolve in the mucous, sending impulses for smell

Vision

Equilibrium

Threshold Stimulus vs. All or Nothing Principle

Chapter 14 - Cardiovascular System

The Heart:

  • Located in the middle of the thoracic cavity in the mediastinum, the space between the two lungs

Layers of the Heart

Pericardium

  • Pericardium Sac: contains the heart, stretches enough to allow for the heart to beat
  • Serous Pericardium: consists of two layers called the parietal layer that lines the pericardial sac and the visceral layer that lines the surface of the heart

Threshold Stimulus

  • Stimulus is strong enough to complete depolarization and then a nerve impulse is generated

All or Nothing Principle

  • Regardless of the intensity of the stimulus, if it was sufficient to cause a neuron to fire, it will generate a nerve impulse across the neuron with uniform strength

Myocardium

  • middle & thickest layer of the heart
  • made up of cardiac cells that allow for stronger contractions of the heart

Epicardium

  • outermost layer, also the visceral layer of the serous pericardium

Endocardium

  • innermost layer of the heart
  • made up of simple squamous epithelium that lines the heart and its chambers

Central Nervous System

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