protein controls salt/water balance inside cells particularly in the lungs

Affects the cells that produce mucus, sweat and digestive juices.

Thick and stick fluids ... plug up tubes, ducts and passageways

Lung. Low Cl secretion into airway lumen = dense surfactant, low mucociliary clearance, infection, inflammation

Pancreas. Low Cl secretion into pancreatic ducts, dehydration/ductal blockage, insufficient enzymes production = maldigestion, malabsorption, gallstones, diabetes (fibrosis = islet cell atrophy like T1, although presents like T2)

Intestine. Low bicarb/Cl secretion in gut, unbuffered gastric secretion. Possible obstruction

Liver. Low Cl secretion in bile ducts, bile acid retention, ductal obstruction = cirrhosis, portal hypertension, oesophageal varices

Increased energy expenditure - inflammation, increased work for lungs (mucous/inflamed airways), infection.

Maldigestion, Malabsorption - exocrine insufficiency, hyperacidity, intestinal mucous

Inadequate intake - poor appetite, disease related anorexia (TNF-a/cytokines), dyspnoea, early satiety, dry mouth, taste changes, behavioural factors

Severe - chronic cough, sputum production, dyspnoea w ADLs, FEV1<40% predicted

Steatorrhea, abdominal cramps, weight loss, chronic cough, dry mouth, fatigue, low appetite, low concentration

GI complications. high viscosity of intestinal mucous, altered motility, gastro-oesophageal reflux