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PFM Biweekly 1 Toxins and Drugs - Coggle Diagram
PFM Biweekly 1 Toxins and Drugs
Na Channel Blockers
Tetrodotoxin
Saxitotoxin
ETC Toxins
Rotenone
Inhibits complex 1 which is oxidizing NADH
Only decrease efficiency of ETC.
Antimycin A
Inhibits Complex 3 which blocks ETC.
Complex 4
Cyanide, Azide, CO
Prevents e- dumping onto oxygen.
Complex 5 or ATP synthase
Oligomycin - comes from streptomyces.
DNA replication Drugs
Topoisomerase 1
Irinotecan
Topoisomerase 2
Ciproflaxin
Inhibits bacterial replication via topoisomerase 1
Etoposide
Doxoribicin
Nucleotide Synthesis Drugs
Salvage Pathway.
Allopurinol
Targets Xanthine oxidase of the purine salvage pathway which breaks down purines to get IMP for later reuse.
Results in lowered Uric acid production.
Probenicid
Increase uric acid excretion
Hydroxyurea and Gemocitbine
Inhibits ribonucleotide reductase, resulting in decreased DNA synthesis. Used in cancer treatment.
6-mercaptopurine
Metabolized to 6-thio-IMP, similar to IMP
Used as a anti-neoplastic drug by inhibiting via feedback the
purine synthesis
by targeting phosphoribosyl pyrophosphate glutamyl aminotransferase (PRPP glutamyl aminotransferase)
Azathioprine (immunosuppressant)
Metabolized to 6 mercaptopurine on its pathway and acts on other indep pathway.
Mycophenolate Mofetil
Inhibits
GMP nucleotide synthesis
via feedback inhibition. Targets
IMP dehydrogenase
RNA Replication Drug
Polymerase
Rifampin
Targets prokaryotic polymerase
Actin Inhibitors
Phalloidin
Stabilize F actin, preventing depolymerization
Cytochalasins
Binds the plus end, preventing growth of actin. This results in depolymerization
Latrunculins
Prevents F-actin incorporation resulting in F-actin depolymerization.
Microtubule Drugs
Vincristin/Vinblastin
Inhibit MT assembly
Taxol (paclitaxel) - stabilizing
Colchicine
Used to treat gout. Acts by depolymerization.
Golgi Toxins
Botulinum toxin
Cleaves SNAREs and block exocytosis of AChe.
Tetanus toxin
Inhibits secretion of inhibitory NT like GABA and glycine
G alpha stimulating protein toxin
Cholera toxin
Inhibits GTPase activity, preventing cAMP breakdown. Results in increased cAMP activity, stimulating Cl- and water secretion= diarrhea
Pertussis
Inactivate G alpha inhibitory protein, causing increased cAMP.