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Controlled drug delivery, Liposomes & Niosomes, Microencapsulation -…
Controlled drug delivery
Ion exchange resins
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Mechanism
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Reversible, selective, stereometeric interchange
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Diffusion
Matrix drug release
- Rigid matrix
• PVP and fatty acids
- Swelleble
• Natural Tragacanth Guar gum
• Semi synthetic HPMC CMC Xanthum
• Synthetic Polyacryalmide
- Glucotrol XL Procardia XL
Membrane/ Reservoir drug release
- Water insoluble non swelleble
• HPC Ethyl cellulose Polyvinyl acetate
- Nico 400 Nitro Bid
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Liposomes & Niosomes
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Application
• DNA delivery
• Cancer therapy
• Drug delivery carriers
• Antigen carriers
• Drug carriers
• Antimicrobial/ Viral
• Tumor
• Diabeties
• Ophthalmic drugs
Microencapsulation
Different techniques
- Chemical
• Phase seperation/ Coacervation tech.
- Phase Coacervation
• Temperature change
• Addition incompatible polymer
• Addition of non solvent
• Salt addition
• Polymer polymer interaction
- Mechanical
• Spray drying/ congealing
• Fluidized bed tech.
• Solvent evaporation
• Extrusion
• Pan coating
• Multi orifice centrifugal tech.