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Mild hyperthermia treatment to reduce tau protein phosphorylation,…

- - - - Long term phosphorylation may be dangerous
- - - - Phosphorylation of tau regulates all these functions
  - - - Alzheimer's and Dementia
  - - - Mild hyperthermia may reduce tau phosphorylation and lessen neurofibrillary entanglements
        
        Using sauna-like conditions and menthol to raise body heat in mice
- - - - Control:
        Wild type
      - Experimental:
        Transgenic mice with mutated tau.
        Tau protein mutated to hyperphosphorylate
  - - - Rectal temperatures taken and mice were decapitated and tissues analyzed
- - - - Reduced phosphorylation activity caused by decrease in Kinase activity and increase in phosphatase activity