Please enable JavaScript.
Coggle requires JavaScript to display documents.
Rhabdomyolysis - Coggle Diagram
Rhabdomyolysis
Complications
Electrolyte
HYperkalaemia
Hypocalcaemia
chelated by phosphate
Hyperuricaemia
Hypovolaemia
Compartment syndrome
DIC
AKI
Myoglobin + Tamm-Horsfall protein
Uric acid
Lipid peroxidation
Haem moiety
Inappropriate renal vasoconstriction
relative deficiency of NO
Causes
Traumatic
Crush injuries
Excessive muscle use
exercise
seizures
tetanus
Electrical current
Non traumatic
Myopathies
Endocrine
hypothyroidism
DKA
Drugs
statins, ,
MDMA
amphetamines
Hyperthermia
Sepsis
NMS
MH
HYpoperfusion
Necrotising faciitis
Electrolyte
Hyperosmotic
Hypokalaemia
Hypophosphatemia
Hyponatraemia
Autoimmune
dermatomyositis
polymyositis
Diagnosis
Triad
Myalgia
weakness
Dark urine
Inx
CK
Urine
microscopy casts
Myoglobulin
ECG
Imaging of injuried area
Management
Medical
Resuscitation
UO 2-3mls/kg
CSL may assist in urinary alkalinisation
Hyperkalameia
Insulin and dextrose
Salbutamol
Calcium chloride
IV fluid
Urinary alklisation
1.26% Sodium bicorbaonate
Aim Urinary pH >6.5
Mannitol
Osmotic effect
Free radcial scavenger
RRT
Surgical
Fasciotomies
Pathophysiology
Muscle ischaemia
ATP depletion
Decreased active transport into the sarcoplasmic reticulum
Hyperactivity of proteases
Release of intracellular contents into the plasma