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γδ T cells, Function Which cells do they influence How do they influence…

- - - - Activates effector function
  - - - Binds to Endothelial protein C receptor (EPCR)
        
        Secrete inflammatory cytokines and kill infected cells
        
        Cell surface protein on virus infected cells and tumor cells
        
        Similar to MHCI, but binds phospholipids
      - Cellular stress recognition
  - - - Can respond to lipids of human self lipids, as well as lipids of microbials
  - - - Dual function microbial infection
- - - - Lack CCR7 chemokine receptor
      - CCR5 receptor
        
        Enter infected tissues,
        respond to invading pathogens
- - - - Commited γδ Tcell
        
        Tcell receptor
      - Uncommited double-negative thymocyte
        
        Comitted γδ T cell
        
        Comitted αβ T cell
        
        CD8, CD4
        
        β chain
      - CD2
  - - - Central memory
        
        Terminally differentiated
        
        CD27-
        CD45RA+
        
        CD27+
        CD45RA-
      - CD27-
        CDRA45-