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Lorazepam - Coggle Diagram
Lorazepam
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Counseling
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Educate patient on the risks & symptoms of abuse, misuse, addiction & to report symptoms
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Mechanism of action
Binds to GABA receptors to increase the frequency of opening of the chloride channel --> hyperpolarization
*No active metabolites
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Monitoring
Monitor: Heart rate, BP, liver function, and LDH.
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Interactions
CNS depressants (alcohol, antidepressants)
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Special Populations
Avoid in older adults, pediatrics, and pregnancy/lactating populations
Regimen
Initial, 2 to 3 mg/day orally divided into 2 to 3 daily doses
Maintenance, 2 to 6 mg/day orally divided into 2 to 3 daily doses; dose may vary from 1 to 10 mg/day
Duration
Generally used short term for symptom relief until preferred therapy (eg, SSRI) is effective (eg, 4 to 6 weeks followed by tapering). Long-term, low-dose (0.5 mg/day) therapy may be considered in select patients when preferred treatments are ineffective or poorly tolerated
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