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Pre RA, neutrophil, angiogenesis, CD4 T cells, FLS, migration to lymphnode…
Pre RA
modification of autoantigens in FLS
Recognition of APC
Activation CD4+ T-cell
Activation B cells in GC (costimulation
Proliferation and Differentiation into plasma cells
Production of auto antibodies
Anti-citrullinated protein antibody
target citrullinated proteins like fibrin (foreign
Rheumatoid factor (IgM 75%)
form immune complexes
can activate the complement proteins
migration to joint tissue
migration to synovium
CD4 T cells
IL 17
Macrophage
3 more items...
Fibroblast-like synoviocytes FLS
2 more items...
Plasma cells
inflammation
immune complex
neutrophil
ROS
chondrocytes
cartilage degradation
angiogenesis
vascular permeability and increase expression of adhesion molecules
CD4 T cells
FLS
proteases production
migration to lymphnode
synovial fluid
synovial fluid
not all cytokines covered. Missing: IL-18, IL-13, IL-12, IL-15, GM-CSF, and M-CSF