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IBD, Diverse factors, macrophage - Coggle Diagram

- - - - targets
        
        natalizumab alfa4 integrin
        
        velolizumab
    - - release inflammatory mediators
      - tissue destruction
      - impairment of epithelial barrier function
- - - - IL-17, 21, 22, g-csf
        
        IL-17 also important intestinal barrier function
      - TARGET: p19, p40 related to IL-12 and 23
      - IL-12, 23
        
        Th1/Th17
    - - SUPRESSOr
        
        not enough in ibd
      - IL-10, TGF-b
    - - IFN gamma
      - tnf alfa
    - - IL-4
      - IL-5 13
      - infiltration of eosinophils
        
        inflammation
    - - IL-10
      - TGF-beta
    - - inducts th1 th2 th17 cytokines, NK, Myeloid and ILC
- - - - Th17
        
        Il-17,21,22
      - Th1
        
        IL-6, tnf alfa, IFN gamma
        
        INFLAMMATION
      - Treg
    - - antibodies