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Rheumatiod Athritis - Coggle Diagram

- - - - induces fever
      - regulates innate immunity
      - T-cell differentiation
      - matrix regulation (matrix metalloproteinases inducer)
    - - inhibition of osteoclast formation
      - local production of TNF and IL-18
  - - - produced by synovial macrophages
      - expression of human leucocyte antigen (HLA)-DR molecules on antigen presenting cells (APCs)
      - initiates T-cell activation
    - - Osteoclast development
  - - - generated by activated T-cells, appear only in small quantities
  - - - AB class switching and allergic diseases, only low quantities
  - - - produced by Th17 cells in synovial tissue
      - enhances IL-6 production and collagen destruction;
      - COX-2 expression, Prostaglandin E2 production
      - osteoclast activation and decreased bone formation
- - - - proliferation of FLS and expression of RANKL
        
        RANKL + Cytokines --> osteoclast activity and bone errosion
  - - - activates component of complement
      - Cartilage destruction, degradation of matrix components
    - - targets citrullinated Proteins (fibrin)
      - spesific marker for RA
- - - - Modificatin of autoantigen
        
        recognistion of APCs and activation
        
        innitiation of immune response
        
        active APC migrates to lymph node and activates CD4+ T-cells
        
        these activate B-cells (co-stimmulation) in Germinal Center
        
        B-cells proliferate, class-switch, become plasmacells
        
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