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Rheumatiod Athritis - Coggle Diagram
Rheumatiod Athritis
Cytokines involved
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TGF-beta
inhibits T-cell activation and proliferaton; downregulates B-cell proliferation and differentiation; inhibits bioynthesis of metalloproteinases; inhiits TNF secretion, wound repair
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Cells involved
Macrophages (1)
create TNF-alpha, IL-1 and IL-6 in synovium
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Antibodies
Rheumatiod factor (IgM)
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Cartilage destruction, degradation of matrix components
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Therapy
anti-TNF therapy
decrease in RANKL/OPG (receptor activator of nuclear factor kB ligand/ Osteoprotegerin) and decrease in local bone resorption
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blocking of JAK1, 2 and 3 (Janus kinase--> cytokine signaling, activation of transcrition through STATs)
Development (Theory)
Trigger
Epigenetic modifications, Genetics; Smoking; Infection of the joint, ...
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