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Memory in the immune system, 2 branches of immunological memory of…
Memory in the immune system
Infection
Primary response
Plasma cells (short-lived effector cells)
Produce + secrete
High-affinity specific antibodies
Pathogen is no longer a threat
Level of circulating ABs gradually decreases and reaches a low, steady-state level
Production of small clones of long-lived plasma cells
Primary response
Naive B cells
Isotype switching, increasing affinity, antigen-mediated selection,
2 branches of immunological memory of pathogens
Memory B cells
Binds pathogen
Becomes antibody-producing plasma cell
Secretes high-affinity IgG (mostly IgG1)
Memory T cells
Stress + speed of this causes cellular damage and mutations
= source of ABs making up the steady state level
Don't express a cell-surface Ig