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proteins and PLGA DDS - Coggle Diagram
proteins and PLGA DDS
particle preparation
low EE
incompatability
instability during preparation
solubility
interaction with polymer
interaction with additives
drying process
stabilizer
storage and release
acidic environment
conformational change
temperature
burst release
incomplete release
unactive protein
degradation products
in vitro release tests
stirring
agitation
detection
stability in release medium
which method?
instabilities
chemical instabilities
physical instabilities