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Dendritic Cells subsets - Coggle Diagram
Dendritic Cells subsets
Plasmacytoid DCs
Position in hematopoiesis
Hematocytoblast > Common myeloid progenitor > granulocyte–macrophage DC progenitor (GMDP), macrophage DC progenitor (MDP), common DC progenitor (CDP) >
plasmacytoid DCs
Transcriptional and/or phenotypical characteristics
TF
IRF8, IRF4
, E2-2, ZEB2, IRF7, NK-κB
Receptors
Extracellular
CD123, CD303/CLEC4C/BDCA‐2, CD304
not expressed: 11B, 11C, 13
Intracellular
TLR7 and TLR9
Function
Response
Upon pathogen encounter, pDCs produce large amounts of
type I IFN
and acquire antigen-presenting capacity.
Effector molecules
Response stimuli
Single-stranded RNA and double-stranded DNA from virus
Summary
Stimulation IRF8 and IRF4
Myeloid cDC1
Position in hematopoiesis
Hematocytoblast>Common myeloid progenitor>granulocyte–macrophage DC progenitor (GMDP), macrophage DC progenitor (MDP), common DC progenitor (CDP) with a final pre-DC stage leading to conventional
DC1 (cDC1)
Transcriptional and/or phenotypical characteristics
TF
IRF8
, GATA2, PU.1, GFI1, Id2 and BATF3
Receptors
Intracellular
TLR3, TLR9, and TLR10
Extracellular
CD45, CD11c, MHC class II, CD8a, XCR1, CD24, CLEC9A
Function
Response
cDC1 perform
cross-presentation
of antigens to MHC class I and start type I cytotoxic immune responses and also promote T helper type 1 (
Th1
) and natural killer responses through IL-12.
Effector molecules
Response stimuli
Sensors for pathogens TLR3, TLr9, dsRNA poly IC, DNA CpG, actin
Intracellular pathogens
Myeloid cDC2s
Position in hematopoiesis
Hematocytoblast>Common myeloid progenitor>granulocyte–macrophage DC progenitor (GMDP), macrophage DC progenitor (MDP), common DC progenitor (CDP) with a final pre-DC stage leading to conventional
DC2 (cDC2)
Transcriptional and/or phenotypical characteristics
TF
IRF4
, GATA2, PU.1, GFI1, ID2, ZEB2, RELB, NOTCH2 and KLF4
Receptors
Intracellular
TLR4, TLR5
,
TLR8, TLR9
Extracellular
CD45, CD11c, MHC class II, CD4, SIRPα, CD11b
Function
Response
Release of IL-8, IL-1, IL.12 (high), IL-23, IL-10, TNF alpha; cross-presenting cells, activation of th1, th2, th17 and CD8+ T cells. cDC2 specialist in MHC class II restricted antigen presentation initiating CD4+ T cell responses.
Effector molecules
Response stimuli
Sensors for pathogens): zymosan lipoproteins, flagellin, LPS, DNA CpG, TLR8, ssRNA base analogues
Parasites, fungi
