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Dendritic cells, pluripotente hematopoietic stem cell, hematopoesis,…

- - - - macrophage DC progenitor
        
        common DC progenitor
        
        pre-DC
        
        myeloid cDC1
        
        cross-present antigens via MHC class I to activate CD8+ T cells and to promote T helper type 1 (Th1) and natural killer responses through IL-12
        
        transcription factors: ID2, ZEB2, IRF4, Notch2, -1, IRF8, TLR3, TLR9 (intracellular) and CD45 (extracellular)
        
        cytokine production: TNF-a, IL-12, CXCL9, CXCL10
        
        react to intracellular pathogens
        
        myeloid cDC2
        
        transcription factors: IRF4, GATA2, PU1
        
        TLR4, TLR5, TLR2, TLR6
        
        produce: TNF-a, IL-12, IL-10, IL-23
        
        response to parasites, extracellular microbes
        
        plasmacytoid DC (pDC)
        
        phenotype: eccentric nucleus and prominent endoplasmic reticulum and golgi (resembling a plasma cell) for the production of type I interferon
        
        transcription factors: IRF8, IRF4, extracellular: receptors CD303/CLEC4C/BDCA-2
        
        type I interferons reponse to
        
        receptors: intracellular TLR7, TLR9
        
        production of IL-6, TNF, Granzym B, IFN-a