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innate lymphoid cell precursor, hematopoietic stem cells - Coggle Diagram
innate lymphoid cell precursor
ILC1
extracellular markers
NKp44
CD127
TRAIL
CD49A
cytokines
stimulated by
intracellular microbes
tumors
produces
granzymes
IFNy
perforin
function
cytotoxicity
macrophage activation
Tissue tolerance and regeneration
transcription factors
NFIL3
RUNX3
TBET
ILC2
extracellular markers
CD161
CRTH2
cytokines
stimulated by
large extracellular antigens
Large extracellular parasites
produces
IL13
IL5
IL4
AREG
function
alternative macrophage activation
eptihelial cell regulation
tissue tolerance and regeneration
transcription factors
RARa
BCL11b
GATA3
GFI
ILC3
cytokines
stimulated by
extracellular microbes, fungi and bacteria
produces
IL22
intestinal homeostasis and proliferation of intestinal stem cells
GM-CSF
IL17
Lymphotoxin
Function
stimulate phagocytosis
produce antimicrobial peptides
tissue tolerance and regeneration
transcription factors
ID2
RORyT
AHR
Mostly located in the mucosa
hematopoietic stem cells
common lymphoid progenitor
common innate lymphoid progenitor
NK cells
cytokines
produces
granzymes
perforin
IFNy
stimulated by
intracellular microbes
tumors
Function
cytotoxicity
regulation of other immune cells (control inflammatory/autoimmune disorders)
extracellular markers
CD56
transcription factors
Eomes
common helper innate lymphoid progenitor