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Dermovate Cream - Coggle Diagram
Dermovate Cream
CQAs
Description/Appearance
ID
Assay & Impurities
Particle size
pH
Viscosity
Oil droplet size
Preservative content
Micro
Fill weight
Side effects
Skin reactions
Spider veins
Adrenal suppression
Excess hair growth!
Contraindications
Untreated skin infections
Acne
Plaque psoriasis
Ingredients
Active
Clobetasol propionate 0.0525%
Excipients
Emollient - Cetostearyl alcohol
Stabiliser - Glyceryl
Beeswax
Preservative - Propylene glycol
Preservative - Chlorocresol
Buffer - Sodium citrate
Purified water
Classification & Dose Form
Topical corticosteroid
Cream, ointment and scale application
Mode of action
Inhibit inflammation by blocking prostaglandins
Inflammation caused by allergens/irritants
Indications
Severe resistant skin inflammation
e.g. Eczemas that don't respond
Manufacturing Process
Micronise API
Dissolve with preservative & buffers @ 80C
Melt waxes @ 70C
Combine oil & aqueous phase
Add emulsifier and stabiliser
High/low shear blending
Cool to thicken @ 45C
Discharge @ 30C