Intraepithelial Leukocytes
TCRαβ+
TCRγδ+
TRC-
CD4+
TCRγδ+CD8αα+
CD8αβ+
TCRαβ+CD4+CD8αα+
TCRαβ+CD8αβ+CD8αα+
Induced
ILC1-like
ILC3-like
iCD8α
iCD3+
Natural
Produce: IFN- , TNF-, TNF-, IL-10, IL-13, KGF
Protect the intestinal epithelium against attack by pathogenic microorganisms and inflammatory insults. Within a few hours, they produce antimicrobial effectors such as the antibacterial lectin REGIII-gamma. They also produce factors that promote the healing of the epithelium. They can also inhibit the activation of other immune cells. Cytotoxic like.
γδ T cells
Function: Secretion of cytokines that induce the repair of damaged tissues
Vγ4:Vδ5
Secrete inflammatory cytokines and kill infected cells similar to cytotoxic T cells.
Vγ:Vδ1
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Innate Lymphoid Cells
Natural Killer Cells
Funcrion
Cytotoxix
Kill pathogen infected cells
Location:
Circulate in the blood
Enter infected tissues
ILC1
ILC2
ILC3
Location
Reside in tissue
Location
Reside in tissue
Location
Reside in tissue
ILC do not express adaptive antigen recognition receptors. Activation is regulated by cytokines, rather than antigen recognition.
ILC reside in the tissue for immeadiate response
Interact wirh DC cells (IL-23), which stimulates IL-22 production by ILCs
Causes epithelium to release Anti-bacterial peptides
respond to extracellular pathogens and participate in the containment of commensal microorganisms in the gut
Also activate macrophages to establish tolerance for commensal microbiota
Response against helminths. The by helminth killed cells release alarmins such as IL-25 and IL-33. Il-25 incudes IL-13 production in ILC2, which is a mediator for mucous production. It also activates DC cells with IL-13. With IL-5 they recruite eosinophils and mast cells and induce muscle contraction. In response to IL-33, they also release amphiregulin. This induces tissue repair following the helminth clearancd