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Adrenergic Drug - Coggle Diagram
Adrenergic Drug
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Adrenergic Antagonists
alpha-adrenergic blocking agents:
--Therapeutic use: Hypertension; Reversal of Toxicity From Alpha1 Agonists; Benign prostatic hyperplasia (BPH); pheochromocytoma; Raynaud’s Disease
--Adverse Effects of Alpha1 Blockade: Orthostatic Hypotension; Reflex Tachycardia; Nasal Congestion; Inhibition of Ejaculation
Selective (Alpha1) Adrenergic Antagonist:
Prazosin--only for hypertension
Tamsulosin--only for BPH
--Patient teaching: change position slowly; AVOID Sildenafil; grapefruit juice is ok for this drug;
--common side effect: headache; orthostativ hypotension
nonselective alpha bloker:
--Phentolamine---- diagnosis and treatment of pheochromocytoma
- as DOPAMINE ANTIDOTE
－Prevention of tissue necrosis after the extravasation of drugs that produce alpha1-mediated vasoconstriction
beta-adrenergic blocking agents:
--Therapeutic use: Angina Pectoris; Hypertension; Cardiac Dysrhythmias; Myocardial Infarction; Reduction of Perioperative Mortality; Heart Failure; Hyperthyroidism;Migraine Prophylaxis; Stage Fright; Pheochromocytoma; Glaucoma
--Adverse Effects of Beta1 Blockade: Bradycardia;Reduced Cardiac Output; Precipitation of Heart Failure;AV Heart Block;Rebound Cardiac Excitation
--Adverse Effects of Beta2 Blockade: Bronchoconstriction; Hypoglycemia From Inhibition of Glycogenolysis
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Selective Beta1 Blocker(second generation): Metoprolol
－－Not likely to cause bronchoconstriction or hypoglycemia
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(1) direct receptor binding
(2) promotion of norepinephrine(NE) release
(3) blockade of NE reuptake
(4)inhibition of NE inactivation by inhibit by monoamineoxidase (MAO)
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