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Phosphate - Coggle Diagram
Phosphate
Homeostatis
Absorbtion
1,25 dihydroxyvitamin D3
Small intestine
Storage
85% in bone
PTH causes reabsorbtion from bone
Excretion
Renally excreted by PCT
Increased by
PTH
Calcitonin
Mg
Vitamin D3
Bicarbonate
Decreased
Sodium reabsorbtion
Roles
Energy
ATP
Membrane
Phospholipid bilayer
RBC
2,3 DPG
Buffer
Bone minerilisation
Definition
Cation
Intracellular
1% of total body weight
Hyperphosphataemia
Causes
Reduced excretion
renal failure
Hypoparathyroidism
Hypomagnesaemia
Exogenous load
Enteral
Parenteral
Enemas
Vitamin D
Increased production
Rhabdomyolysis
Tumour lysis syndrome
Malignant hyperpyrexia
Complications
Hypocalcaemia
Tetany
Nephrocalcinosis
Management
Aluminium hydroxide
Loop diuretics
Stop administering phophate
Hypophosphataemia
Causes
Renal loss
HYperaldosteronism
Hyperparathyroidism
Renal tubular acidosis
Alcohol
Acetazolamide
Increased glycolysis
Refeeding syndrome
DKA
Sepsis
Hyperinsulinaemia
Cortisol
Adrenalin
GI Loss
Antiacid abuse
Vitamin D deficiency
Diarrhoea
Complications
Neuromuscular
Smooth muscle dysfunction
Cardiomyopathy
Treatment
POtassium Diphophate 10mmol
Phosphate polyfusor 100mmol
Indicated if less than 0.32