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Pharmokinetics - Coggle Diagram
Pharmokinetics
Defintion
dose administered
Change in drug concentration over time
effect of the body on the drug
Pharmacodynamics
drug concentration
Pharmacological effect on target site
Drug on the body
Processes
Absorbtion
Patient factors
Malabsorbtion
Drug factors
Smaler particle size = faster
first past metabolism
metabolic capacity
protein binding
Route
Sublingual aviods FPM
IM rate dependes on local blood flow
Distribution
Regional blood flow
Cell membrane
Moecular size
Concentration gradient
FIcks law
Ionisation
pKa
Lipid solubility
Protein binding
Facilitated diffusion vs active transport
Metabolism
Phase 1 (non synthetic)
Oxudation
Reduction
Hydrolysis
Phase 2
Glucuronidation
Sulphation
Acetylation
Methylation
Critically ill
Absorbtion
Delayed
Gastric emptying
ILeus
Altered gastric pH
Impaired
diarrhoea
Bacterial overgrowth
Villous atrophy
Distribution
Hepatic metabolism
Reduced
Blood flow
Hepative injury
Hypothermia
Increased
Hyperthermia
Reduced degradation
Hoffman degradation
Acidosis
Hypothermia
plasma cholinesterase deficiency
Excretion
Renal clearance
HYpoperfusion
<eGFR
Direct renal injury
ATN
Biliary
stasis
re-circulation due to transit time
RRT
Methanol
Metformin
Methotrexate
Carbmazepine
Lithium
Aspirin
Valproate
Aminoglycosides
Theophyllines
Ethylene glycol
Metabolism
Inducers (CRAPGPS)
Carbmazepines
Rifampicin
Alcohol
Phenytoin
Griseofluvin
Sulphonureas
Inhibitors (SICKFACES.COM)
Sodium Valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol & Grapefruit
Chloramphenicol
Erythrmycin
Sulfonamides
Ciprofloxacin
Omeprazole
Metroniadazole
Zero order kinetics (PWHEATS)
Phenytoin
Warfarin
Heparin
Ethanol
Aspirin
Theophylline
Salicylates