Please enable JavaScript.
Coggle requires JavaScript to display documents.
Novel Anticoagulation - Coggle Diagram
Novel Anticoagulation
Types
Direct thrombin inhibitors
Dabigatran
Reversal: idacaruzumab
Direct 10 a inhibitors
Rivaroxeban
apixeban
Reversal: Andexanet alfa
Indirect 10 a inhibitors
Fundaparinox
Indications
Non valvular AF
VTE
After elective hip / knee replacement
NOACS
ADvantages
Rapid onset
Short half lives
Similar / improved efficacy
Fewer interations
No need for monitoring
No requirement for bridging
Fixed dosing
Fewar complications
Disadvantages
No specific antidote
No widely available measure of activity
Limited experience
Effect of renal impairment on pharmokinetics