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Myasthenia Gravis - Coggle Diagram
Myasthenia Gravis
Diagnosis
Clinical features
Fatiguable weakness
Diplopia and ptosis
Electromyography
Progressive smaller action potentials
Edrophonium (Tensilon) Test
10mg rapid acting cholinesterase inhibitor
Rapid improvement with MG
Risk of bradycardia and heart block
Serum
AChR Antibodies
MUSK antibodies
Mysthenic crisis
Characteristics
FVC <1 litre
Neg inspiratory force <20cm H20
Need for mechnical respiratory support
Risk factors
infection
treatment omission
pregnancy
Drugs
Antibiotics
Anticonvulsants
Anaesthetic agents
Cardiovascular medications
Other
OCP
Magnesium
Acetazolamide
CHolinergic crisis
SLUDGE
Salivation
Lacrimation
Urination
Defacation
Gastrointestinal cramps
Emesis
Indications for intubation
Neg inspiratory pressure <30cmH20
VC <20ml/kg
Hypercapnoia
Bulbar dysfunction
Description
ACquired autoimmune condition
IgG antibodies post synaptic AchR at the nicotinic nueuromuscular junction
Management
Medical
Cholinesterase inhibition
Pyridostigmine
Muscarinic side effects
Immunosuppression
Corticosteriods
Aziothiprine
Cyclosporin
Plasma exchange
Surgical
Thymectomy