Please enable JavaScript.
Coggle requires JavaScript to display documents.
HUS - TTP - Coggle Diagram
HUS - TTP
Pathohysiology
vWF cleaving protease
ADAMTS13 - check levels
Genetic eg absence of protein
acquires antibody
Uncontrolled platelet activation
Fibrin + thrombus propagated
Pentad
MAHA
Thrombocytonpenia
Renal fialure
Neurological signs
Fever
Triad
MAHA
Thrombocytopenia
Renal Failure
HUS
Causes
Typical
Shigella
eColi 0157
Atypical
Infection
CMV
HIV
Strep pnumoniae
Bone marrow transplant
Drugs
quinine
heroin
ciclosporin
Malignancy
Pregnancy
Management
Direct coombs test
Urinalysis
LDH, conjugated/unconjugated bilirubin, haptoglobin
Ciprofloxacin for e.coli
PLasma exchange
TTP
Management
PLasma exchange
Daily
Continues 2 days post platelet recovery
Octaplas - contains deficient in vWF
High dose methyprednisalone
Rituximab
Aspirin
Supportive measures
PLatelets transfusion contraindicated