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Platelets and Hemostasis
30 Aug, Thrombin, Anti coagulants, Vitamin K,…
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Thrombin
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Activates Factor XIII, to stabilise Fibrin
Releases PF 3, which aids in the intrinsic pathway
Releases TF, which aids in the extrinsic pathway
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Vitamin K
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Inhibits activation of X, XI, VII, II (1972)
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Inhibitors
- Prostacyclin
- Nitric oxide
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Prothrombin Time (PT)
Time for plasma sample to clot after adding Factor III (TF) and Factor IV (Calcium)
- Extrinsic Pathway.
- Average time is 11-13 seconds
- International
Normalized Ratio (INR) = Test/Normal
Activated Partial Thromboplastin Time (aPTT)
aPTT measures clotting time of plasma, by adding Factor XII activators, ie silica.
- Reference range 25-40 seconds.
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