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Bordetella pertussis - Coggle Diagram
Bordetella pertussis
Toxins
Pertussis toxin
ribosylation
inhibits Gi
leads to rise in cAMP
Lymphocytosis
Adenylate cyclase toxin
causes increase in cAMP
Tracheal toxin
part of peptidoglycan layer of pertussis
damages ciliated epithelium of respiratory tract
Clinical findings
Catarl phase
peroxismal stage
whooping cough
convalescent stage
gradual reduction in symptoms
"100 day cough"
Treatment
macrolides
not effective if toxins already circulating
Spreads by respiratory droplets
Attaches via pilli
Filamentous Hemaglutinin
Ab's against it help protect against infection
Prevention
Two vaccines
Killed - not available
Acellular
purified antigens
DTaP
Causes whooping cough
Highly contagious