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neuropsychology, Lewy Body Disease - Coggle Diagram

- - - - nicotinic
      - muscarinic
    - - catecholamines
        
        Dopamine
        
        mesostriatal pathway
        
        mesolimbic pathway
        
        mesocortical pathway
        
        Norepinephrine
        
        noradrenergic
        
        Epinephrine
      - indoleamines
        
        serotonin
        
        melatonin
      - histamine
    - - glutamate
      - GABA
      - ATP and adenosine
- - - - Mutations on APP, PSEN1 or PSEN2, or e4 allele of APOE
      - Oxidisation Stress
      - Age related disruption to microRNA
    - - Biomarkers in CSF
      - Symptoms
        
        Disinhibition, apathy, lack of empathy, ritualistic behaviours, language difficulties, dietary changes
      - Amyloid plaques (misfolded beta amyloid)
  - - - Methamphetamine
      - Alcohol
        
        Korsakoff Syndrome
      - Cocaine, Opioids, Phencyclidine (PCP), Sedatives, Hypnotics, Anti-anxiety drugs, Solvents
    - - Abstention from substance
    - - Cognitive difficulties in correlation to a recreational or therapeutic drug, outside of intoxication or withdrawal
  - - - Transmissible Spongiform Encephalopathies (TSEs)
        
        Creutzfeldt-Jakobs Disease (CJD)
        
        Kuru
        
        Fatal Familial Insomnia
        
        BSE - vCJD
    - - none - but can be prevented by avoidance of contaminated medical instruments, foods and tissues
    - - Symptoms
        
        Paranoia, anxiety, depression, dementia, motor disturbances
      - Post-mortem examination
        
        Brain tissue is sponge-like, hence ''spongiform''