Please enable JavaScript.

Coggle requires JavaScript to display documents.

*X Chr. Inactivation - Coggle Diagram

- - - - An X w/out an XIC cannot be inactivated
      - An autosomal cell w/ an XIC may become inactivated
  - - - Xist is the inactivating agent
        
        It is transcribed from Xi and inactivates the chromosome it was transcribed from
        
        The Xist coating spreads over the chromosome from the XIC (it is possible for this to spread to an autosomal translocation if present
    - - DNA Methylation patterns are passed on to daughter cells, which is what maintains X inactivation
- - - - 45,X0
      - Normal intelligence
      - Short stature
      - 90% ovaries w/ few/absent follicles (Amenorrhea)
    - - Typically: 47,XXY
      - Tall, hypogonadism, some learning difficulties, low testosterone in adults
      - Other karyotypes
        
        48,XXYY
        
        48,XXXY
        
        49,XXXXY
  - - - Increased expression of XCI escapees may contribute to increased frequency in females