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DRUG DISTRIBUTION - Coggle Diagram
DRUG DISTRIBUTION
FACTORS AFFECTING
drug characteristic
hydrophobic drugs
-no net charge
-dissolve in lipid membranes
-permeate into cell
-vd depends on blood flow to the area
hydrophilic drugs:
-non uniform electron distribution
-do not penetrate cell membrane
-must go through slit junctions
- factor influence: molecular weight
blood flow to the tissue
greater blood flow to
brain, kidney,liver
lower rate blood flow to
skeletal muscles, adipose tissue
thiopental, rapidly move into CNS and produce anaesthesia
-high blood flow
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binding of drug
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albumin
-binds many acidic drugs (phenobarbital, aspirin, sulfonamides, warfarin)
alpha acid glycoprotein
-binds basic drugs (diazepam, propanolol, atropine, chloroquine)
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DEFINITION
process by which drug reversibly leaves bloodstream and enters the interstitium (plasma, extracellular fluid) and the cells of the tissues
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