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Drugs Acting on Sympathetic Nervous System - Coggle Diagram
Drugs Acting on Sympathetic Nervous System
Sympathomime drugs ;Adrenergic Activating Drungs
Sympathommetic drugs have 2 mode of action
Direct activation
Indirect activation
Epinephrine or norepinephrine is primary neurotransmitter of sympathe nervous system
Adrenergic receptor
Beta receptor
Beta1
Herat rate
Myocardial contractility
Beta2
Peripheral resistance
blood flow
Vasodilation
Smooth muscle relaxtion
Beta3
RElaxes detrusor miscle
Dopamine receptor
D1-D5
Alpha receptor ; Alpha 1
Blood pressure
Mydriasis
Peripheral resistance
Closure bladder
Vasoconstriction
Alpha2
Inhibit Ach
Inhibit insulin release
Inhibit NE release
Platelet agregationg
Adrenegic Antagonists
Mixed acting
ephedrine Alpha1, Alpha 2, Beta1, Beta 2,and releasing agent
Response is reduced by prior trement with reserpine or guanethidine
Indirect acting
Uptake Inhibitor
cocaine
MAO Inhibtors
selegiline
amphetamine tyramine
Releasing Agents
Responese are abolished by prior treatment with reserpine or guanethidine
COMT Inhibitors
entacapone
Direct acting
Selective
Alpha-2 clonidine
Beta-1 dobutamine
Alpha1-phenypahrine
Beta-2 terbutaline
Nonselective
Alpha-1 Alpha-2 oxymetszoline
Beta-1 Beta-2 isoproterenol
Alpha1, Alpha-2, Beta-1, Beta-2 epinephrin
Responses are not reduced by prior treatment with reserpine or quanethidine Response my by potentiated by cocaine reserpine and guanethidine
ephedrine Alpha1 , Alpha 2, Beta 1 norepinephrine
Sympatholytic drugs ; Adrenergic Blockng Drug
Adrenergic Receptor Antagonists
Alpha Receptor Antagonists
Alpha1-selective
doxazosin
alfuzosin
terazosin
tamsulosin
indoramin
prazosin
urapidil
bunazosin
Alpha2-selective
yohimbine
Non-selective
phenoxybenzamine
phentomine
Beta Receptor Antagonists
Beta1-selective ; Second Generation
bisoprolol
esmolol
atenolol
metoprolol
acebutolol
Non-selective ; Third Generation
carvedilol
bucinodolol
carteolol
labetalol
Non-selective;first Generation
timolol
sotalol
propranolol
levobunolol
pindolol
penbutolol
metipranolol
nadolol
Beta1-selactive ; Third Genaration
celiprolol
nebivolol
betaxolol
Adrenrgic Neuron Blocking Agents
Methyldopa
Reduce BP by active CNS alpha 2 receptor
ADR; postural hypotension, sedation
Guanethidine
Inhibits the release of NE from sympathetic nerve endings
ADR; symptomatic postural hypotension and hypotension following exercise, commonly causes diarrhea from gastrointestinal motility
Reserpine
ADRเข้าสมองได้ทำให้ Domone striatum ลดลง เกิดอาการคล้ายโรค Pakinson
Bretylium
ADR; symptomatic postural hypotension and hypotension fillowing execise
Metyrosine
ADR; confusion,hallucinations,tremors or muscle spaams