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Analgesic Deconstruction, *Ibuprofen denoted as I, *Paracetamol denoted as…
Analgesic Deconstruction
Chemical method
1. Indicator
Phenolpthalein
P: Pink
I: Colourless
A: Colourless
Yellow litmus paper
A: Red
I: Red
P: Blue
Universal
A: yellow-green
I: yellow-green
P: green-blue
2. Neutralisation
Strong acid (HCl)
I: No reaction
A: No reaction
P: Reaction
Strong base (CaCO3, limewater test)
I: Positive - cloudy
A: Positive - cloudy
P: Negative - clear
3. Acidified Dichromate Solution
A: Negative
I: Negative
P: Negative
4. Tollens Reagent
I: Negative - no silver mirror
A: Negative - no silver mirror
P: Positive - silver mirror
6. Odour test (addition of water)
A: Vinegar-like odour
I: Characteristic odour
P: No odour
5. Ferric chloride test (after acidic hydrolysis)
P: Positive - colour change (yellow to violet)
I: Negative - no colour change (yellow)
A: Positive - colour change (yellow to violet)
7. Fractional Distillation (acidic hydrolysis)
Reaction/Product
P: Yes
Salicylic acid
Test: Ferric chloride/ acidified dichromate
Acetic acid
I: No
A: Yes
4-aminophenol
Test: Ferric chloride/ acidified dicrhomate
Acetic acid
Physical method
2. Chromatography
Materials
Chemicals
Ethanol
Acetone
Cyclohexane
Equipment
Micro test tubes
Micropipette
Visualiser: UV light
TLC plate
Beakers
Tweezers
Watchglass
Stationary phase
Polar TLC plate
Mobile phase
50:50 Polar & Nonpolar solvents
1. Solubility
Solvents
Ethanol
Dimethyl formamide
Water
3. Melting point
Equipment
Melting point apparatus
Thermometer
Bunsen burner
Matches
Fire-proof mat
Properties
Melting point
I: 76°C
A: 135°C
P: 170°C
Water solubility
A: 3.0 mg/100mL
I: 2.1mg/100mL
P: 1.4mg/100ml
Acidic/basic nature
I: weak acid
P: weak acid
A: weak base
*Ibuprofen denoted as I
*Paracetamol denoted as P
*Aspirin denoted as A