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ความเป็นพิษ ต่อหน่วยพันธุกรรม 4 - Coggle Diagram

- - - - removal of the damaged base by a DNA glycosylase DNA. glycosylases each enzyme responsible for identifying and removing a specific kind of base damage..
      - removal of its deoxyribose phosphate in the backbone, producing a gap. We have two genes encoding enzymes with this function.
      - replacement with the correct nucleotide. This relies on DNA polymerase beta, one of at least 11 DNA polymerases encoded by our genes.
      - ligation of the break in the strand. Two enzymes are known that can do this; both require ATP to provide the needed energy.
    - - NER differs from BER in several ways
        
        –It uses different enzymes.
        
        –Even though there may be only a single "bad" base to correct,
        
        –its nucleotide is removed along with many other adjacent nucleotides; that is, NER removes a large "patch" around the damage.